194IndexHHeinz bodies 142, 156HELLP syndrome 144Hematocrit 10Hematopoiesisextramedullary 30, 32see also ErythropoiesisHemoglobinassay 10, 128deficiency 132mean cell hemoglobin content(MCH) 10, 13, 128mean cellular hemoglobin concentration(MCHC) 10, 11, 13normal ranges <strong>and</strong> mean values 13see also AnemiaHemoglobinopathies 144Hemolysis 32, 54, 138–139, 142–143Hemolytic uremic syndrome (HUS)144Hemophagocytosis 46HEMPAS antigen 148Hepatitis 66Histiocytes 118reticular 58sea-blue 118Hodgkin cells 176, 177Hodgkin disease 26, 70, 176, 177eosinophilia 124Howell–Jolly bodies 139, 156, 157Hypereosinophilia syndrome 124Hypergammaglobulinemia 82, 131differential diagnosis 82Hypersensitivity reactions 44eosinophilia <strong>and</strong> 124Hyperthyroidism 66Hypogammaglobulinemia 74, 82IIgM paraprotein 78Immunoblasts 176Immunocytoma, lymphoplasmacytoid70–71, 74, 77–78, 183Immunothrombocytopenia 165drug-induced 164–166idiopathic 166secondary 166Infection 36, 40, 46, 48, 112–113anemia <strong>and</strong> 134basophilia <strong>and</strong> 124eosinophilia <strong>and</strong> 124thrombocytopenia <strong>and</strong> 168see also specific infectionsInfectious lymphocytosis 66Infectious mononucleosis 68–69Influenza 168Irondeficiency 7, 56, 128–133blood cell analysis 132bone marrow analysis 136normal ranges 132Iron staining 56, 57, 109Isoantibodies 142LLanghans giant cells 180, 181Leukemia 8, 34, 40, 90–91acute 90–105basophilic 126bone marrow analysis 54characteristics 96classifications 91–93, 94, 104diagnosis 91–94eosinophilic 124erythroleukemia 30, 93, 100lymphocytic (ALL) 104–105classification 104mast cell 126megakaryoblastic 102megakaryocytic 93monoblastic 93, 100–101monocytic 46, 89, 93, 100myeloblastic 96myeloid (AML) 89, 92, 94–97hypoplastic 102, 103with dysplasia 102, 103myelomonocytic 92, 98, 99promyelocytic 92, 98, 99aleukemic 149B-prolymphocytic (B-PLL) 70, 74, 77chronicbasophilic 126lymphocytic (CLL) 66, 70, 74–79,90characteristics 76staging 76, 78myeloid (CML) 26, 44, 56, 90,114–121
Index195blast crisis 120–121bone marrow analysis 118–119,120, 121characteristics 116, 124diagnosis 54, 111, 116–119myelomonocytic (CMML) 89, 90,107, 108eosinophilic 124erythroleukemia 30hairy cell (HCL) 71, 80, 81variant (HCL-V) 80lymphoplasmacytic 71megalokaryocytes 50peroxidase-negative 91peroxidase-positive 91plasma cell 48, 78, 82pseudo-Pelger granulocytes 42T-prolymphocytic 74, 77Leukemic hiatus 91Leukocyte alkaline phosphatase 54Leukocytes 3–4counts 14, 16, 25, 90–91normal ranges <strong>and</strong> mean values 12Leukocytopenia 80, 107Leukocytosis 63, 110smoker's 111Leukopenia 63Listeriosis 179Loeffler syndrome 124Lung aspirates 186–187Lymph node biopsy 23, 24, 174–183metastatic disease 182, 183non-Hodgkin lymphoma 182, 183reactive lymph node hyperplasia176–179sarcoidosis 180–181tuberculosis 180–181Lymphadenitisreactive 176, 178–179tuberculous 181Lymphadenoma 54, 149chronic 74marginal zone 78, 80Lymphatic cells 63, 66cerebrospinal fluid 188differentiation in non-Hodgkinlymphoma 72–73reactive lymphocytosis 66–67see also LymphocytesLymphoblasts 32, 176acute lymphoblastic leukemia (ALL)104–105Lymphocytes 3, 4, 33, 48–49bone marrow 56diagnostic implications 48, 56, 66functions 6in infectious mononucleosis 68–69large granulated (LGL) 69normal ranges <strong>and</strong> mean values 12plasmacytoid 77, 176see also Lymphocytosis; LymphomaLymphocytopoiesis 3Lymphocytosis 66–69, 74, 76constitutional relative 66infectious 66reactive 66–67, 86–87Lymphogranulomatosis see HodgkindiseaseLymphoma 69, 77, 82, 174B-cell 70, 71Burkitt 71centroblastic 71centrocytic 71classification 70–72follicular 71, 78, 79large-cell 71, 74lymphoblastic 72lymphoplasmacytic 78malignant 26mantle cell 71, 78, 79, 189marginal zone 71monocytoid 71non-Hodgkin (NHL) 26, 70–73blastic 70cell surface markers 72–73lymph node biopsy 182, 183precursor 70reactive 176–179diagnosis 178–179splenic lymphoma with villouslymphocytes (SLVL) 80, 81T-cell 72cutaneous (CTCL) 74, 77Lymphomatous toxoplasmosis 66MMacroblasts 30Macrocytes 130, 153Macrophages 5–6, 59iron-storage 57, 58, 136role in erythropoiesis 30, 32Malaria 19, 158–161
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iiiColor Atlas of HematologyPractic
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vPrefaceOur Current EditionAlthough
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viiContentsPhysiology and Pathophys
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ContentsixAcute Lymphoblastic Leuke
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2Physiology and Pathophysiology of
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4Physiology and Pathophysiology of
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6Physiology and Pathophysiology of
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8Physiology and Pathophysiology of
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10Physiology and Pathophysiology of
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12Physiology and Pathophysiology of
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14Physiology and Pathophysiology of
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16Physiology and Pathophysiology of
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18Physiology and Pathophysiology of
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20Physiology and Pathophysiology of
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22Physiology and Pathophysiology of
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24Physiology and Pathophysiology of
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26Physiology and Pathophysiology of
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Normal Cells of the Blood andHemato
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Normally erythropoiesis takes place
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34Normal Cells of the Blood and Hem
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36Normal Cells of the Blood and Hem
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Advancing nuclear contraction and s
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Note the granulations, inclusions,
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44Normal Cells of the Blood and Hem
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46Normal Cells of the Blood and Hem
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48Normal Cells of the Blood and Hem
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50Normal Cells of the Blood and Hem
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52Normal Cells of the Blood and Hem
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54Normal Cells of the Blood and Hem
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56Normal Cells of the Blood and Hem
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58Normal Cells of the Blood and Hem
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Abnormalities of the White Cell Ser
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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During lymphatic reactive states, v
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Extreme transformation of lymphocyt
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Monotonous proliferation of small l
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Atypical lymphocytes are not part o
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Deep nuclear indentation suggests f
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Cytoplasmic processes the main feat
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Plasmacytoma cannot be diagnosed wi
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Atypias and differential diagnoses
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Bone marrow diagnosis is indicated
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Conspicuously large numbers of mono
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Fundamental characteristic of acute
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The diagnosis of acute leukemia is
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Acute leukemias may also derive fro
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New WHO classification: AML with dy
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The cells in acute lymphocytic leuk
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In unexplained anemia and/or leukoc
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The classification of myelodysplasi
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Prevalence of Polynuclear (Segmente
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Predominance of the granulocytic li
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Prevalence of Polynuclear (Segmente
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Left shift as far as myeloblasts, p
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Bone marrow analysis is not obligat
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In the course of chronic myeloid le
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Enlarged spleen and presence of imm
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Eosinophilia and basophilia are usu
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Erythrocyte and ThrombocyteAbnormal
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Hypochromic Anemias129Insufficient
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Hypochromic Anemias131BSGIron Ferri
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Small, hemoglobin-poor erythrocytes
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Hypochromic erythrocytes of very va
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Hypochromic Anemias137Hypochromic S
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Hypochromic anemia without iron def
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Consistently elevated “young” e
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