Color Atlas of Hematology - Practical Microscopic and Clinical ...

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ivLibrary of Congress Cataloging-in-PublicationData is available from the publisherThis book is an authorized revisedtranslation of the 5th German editionpublished and copyrighted 2002 byThieme Verlag, Stuttgart, Germany.Title of the German edition:Taschenatlas der HämatologieTranslator: Ursula Peter-Czichi PhD,Atlanta, GA, USA1st German edition 19832nd German edition 19863rd German edition 19914th German edition 19985th German edition 20021st English edition 19851st French edition 19852nd French edition 20001st Indonesion edition 19891st Italian edition 19841st Japanese edition 1997Important note: Medicine is an everchangingscience undergoing continualdevelopment. Research and clinical experienceare continually expanding ourknowledge, in particular our knowledge ofproper treatment and drug therapy. Insofaras this book mentions any dosage or application,readers may rest assured that theauthors, editors, and publishers have madeevery effort to ensure that such referencesare in accordance with the state of knowledgeat the time of production of thebook.Nevertheless, this does not involve, imply,or express any guarantee or responsibilityon the part of the publishers in respect toany dosage instructions and forms of applicationsstated in the book. Every user is requestedto examine carefully the manufacturers’leaflets accompanying each drugand to check, if necessary in consultationwith a physician or specialist, whether thedosage schedules mentioned therein or thecontraindications stated by the manufacturersdiffer from the statements made inthe present book. Such examination is particularlyimportant with drugs that areeither rarely used or have been newly releasedon the market. Every dosageschedule or every form of application usedis entirely at the user’s own risk and responsibility.The authors and publishers requestevery user to report to the publishersany discrepancies or inaccuracies noticed. 2004 Georg Thieme VerlagRüdigerstraße 14, 70469 Stuttgart,Germanyhttp://www.thieme.deThieme New York, 333 Seventh Avenue,New York, NY 10001 USAhttp://www.thieme.comCover design: Cyclus, StuttgartTypesetting and printing in Germany byDruckhaus Götz GmbH, LudwigsburgISBN 3-13-673102-6 (GTV)ISBN 1-58890-193-9 (TNY) 1 2 3 4 5Some of the product names, patents, andregistered designs referred to in this bookare in fact registered trademarks or proprietarynames even though specific referenceto this fact is not always made in thetext. Therefore, the appearance of a namewithout designation as proprietary is not tobe construed as a representation by thepublisher that it is in the public domain.This book, including all parts thereof, is legallyprotected by copyright. Any use, exploitation,or commercialization outsidethe narrow limits set by copyright legislation,without the publisher’s consent, is illegaland liable to prosecution. This applies inparticular to photostat reproduction, copying,mimeographing, preparation of microfilms,and electronic data processing andstorage.
vPrefaceOur Current EditionAlthough this is the second English edition of our hematology atlas, thisedition is completely new. As an immediate sign of this change, there arenow three authors. The completely updated visual presentation uses digitalimages, and the content is organized according to the most up-to-datemorphological classification criteria.In this new edition, our newly formed team of authors from Munich(the “Munich Group”) has successfully shared their knowledge with you.Heinz Diem and Torsten Haferlach are nationally recognized as lecturersof the diagnostics curriculum of the German Association for Hematologyand Oncology.GoalsMost physicians are fundamentally “visually oriented.” Apart from immediatepatient care, the microscopic analysis of blood plays to this preference.This explains the delight and level of involvement on the part ofpractitioners in the pursuit of morphological analyses.Specialization notwithstanding, the hematologist wants to preservethe opportunity to perform groundbreaking diagnostics in hematology forthe general practitioner, surgeon, pediatrician, the MTA technician, and allmedical support personnel. New colleagues must also be won to thecause. Utmost attention to the analysis of hematological changes is essentialfor a timely diagnosis.Even before bone marrow cytology, cytochemistry, or immunocytochemistry,information based on the analysis of blood is of immediate relevancein the doctor’s office. It is central to the diagnosis of the diseases ofthe blood cell systems themselves, which make their presence knownthrough changes in blood components.The exhaustive quantitative and qualitative use of hematological diagnosticsis crucial. Discussions with colleagues from all specialties andteaching experience with advanced medical students confirm its importance.In cases where a diagnosis remains elusive, the awareness of thenext diagnostic step becomes relevant. Then, further investigationthrough bone marrow, lymph node, or organ tissue cytology can yield firmresults. This pocket atlas offers the basic knowledge for the use of thesetechniques as well.
Page 3: iiiColor Atlas of HematologyPractic
Page 7 and 8: viiContentsPhysiology and Pathophys
Page 9 and 10: ContentsixAcute Lymphoblastic Leuke
Page 12 and 13: 2Physiology and Pathophysiology of
Page 39 and 40: Normal Cells of the Blood andHemato
Page 41: Normally erythropoiesis takes place
Page 44 and 45: 34Normal Cells of the Blood and Hem
Page 46 and 47: 36Normal Cells of the Blood and Hem
Page 49 and 50: Advancing nuclear contraction and s
Page 51: Note the granulations, inclusions,
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44Normal Cells of the Blood and Hem
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Page 71 and 72:
Abnormalities of the White Cell Ser
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Predominance of Mononuclear Round t
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During lymphatic reactive states, v
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Extreme transformation of lymphocyt
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Monotonous proliferation of small l
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Atypical lymphocytes are not part o
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Deep nuclear indentation suggests f
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Cytoplasmic processes the main feat
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Plasmacytoma cannot be diagnosed wi
Page 95 and 96:
Atypias and differential diagnoses
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Bone marrow diagnosis is indicated
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Conspicuously large numbers of mono
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Fundamental characteristic of acute
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The diagnosis of acute leukemia is
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Acute leukemias may also derive fro
Page 113 and 114:
New WHO classification: AML with dy
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The cells in acute lymphocytic leuk
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In unexplained anemia and/or leukoc
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The classification of myelodysplasi
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Prevalence of Polynuclear (Segmente
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Predominance of the granulocytic li
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Prevalence of Polynuclear (Segmente
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Left shift as far as myeloblasts, p
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Bone marrow analysis is not obligat
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In the course of chronic myeloid le
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Enlarged spleen and presence of imm
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Eosinophilia and basophilia are usu
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Erythrocyte and ThrombocyteAbnormal
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Hypochromic Anemias129Insufficient
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Hypochromic Anemias131BSGIron Ferri
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Small, hemoglobin-poor erythrocytes
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Hypochromic erythrocytes of very va
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Hypochromic Anemias137Hypochromic S
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Hypochromic anemia without iron def
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Consistently elevated “young” e
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Distribution pattern and shape of e
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Conspicuous erythrocyte morphology
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Unexplained decrease in cell counts
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Hypochromic Anemias149Differential
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Thrombocytopenia with leukocytosis
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Conspicuous large erythrocytes sugg
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In older patients, myelodysplastic
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Small inclusions are usually a sign
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PlasmodiumfalciparumPlasmodiumvivax
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Conspicuous erythrocyte inclusions
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Bone marrow analysis contributes to
Page 175 and 176:
Thrombocytes: increases, reductions
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Thrombocytes: increases, reductions
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Variant forms of thrombocyte and me
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Thrombocyte proliferation with larg
Page 183 and 184:
Cytology of Organ Biopsiesand Exuda
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Lymph Node Cytology175Anamnesis- su
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Reactive lymph node hyperplasia and
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Lymph Node Cytology179Contact witha
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Epithelioid cells dominate the lymp
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In cases of non-Hodgkin lymphoma an
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Accessible cysts (e.g., branchial c
Page 197 and 198:
Tumor cells can be identified in pl
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Viral, bacterial, and malignant men
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191IndexAActinomycosis 179Addison d
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Index193Disseminated intravascularc
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Index195blast crisis 120-121bone ma
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Index197in hemolytic anemia 140orth
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