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Psychedelic-information-theory-Shamanism-in-the-age-of-Reason

Psychedelic-information-theory-Shamanism-in-the-age-of-Reason

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pixel groups may correspond to actual hot-spots <strong>of</strong> neural activity <strong>in</strong> <strong>the</strong>columns <strong>of</strong> <strong>the</strong> visual cortex. These hot-spots are producedspontaneously <strong>in</strong> <strong>the</strong> wake <strong>of</strong> stimulus, creat<strong>in</strong>g a flood <strong>of</strong> glutamatewherever shafts <strong>of</strong> apical dendrites <strong>in</strong>tersect with lateral projectionsfrom proximal neural columns. 18 Glutamate flood<strong>in</strong>g at dendriticcolumns <strong>of</strong> pyramidal neurons is presumably <strong>the</strong> result <strong>of</strong>asynchronous glutamate release <strong>in</strong> <strong>the</strong> wake <strong>of</strong> 5-HT 2A receptoragonism. 19Figure 19. Muscles <strong>of</strong> <strong>the</strong> eye. Some subjects on psychedelics report pulsations<strong>in</strong> optic muscles that adjust and control focus, specifically <strong>the</strong> lateral rectus and<strong>in</strong>ferior oblique. These pulsations may be directly related to frequency <strong>of</strong>halluc<strong>in</strong>ogenic <strong>in</strong>terrupt. From Grey’s Anatomy.It is widely assumed that geometric halluc<strong>in</strong>ations and flickerphosphenes orig<strong>in</strong>ate between <strong>the</strong> optic track and cortex, but somesubjective reports <strong>of</strong> psychedelic experimentation also describe a fastpulsation or rhythmic jitter felt <strong>in</strong> <strong>the</strong> muscles around <strong>the</strong> eyes. Thissensation is most acute <strong>in</strong> <strong>the</strong> outside corner <strong>of</strong> <strong>the</strong> visual periphery,specifically along <strong>the</strong> lateral rectus and <strong>the</strong> junction where <strong>the</strong> <strong>in</strong>ferioroblique passes over <strong>the</strong> <strong>in</strong>ferior rectus (Fig. 19). This optical pulse maybe difficult to discern <strong>in</strong> early parts <strong>of</strong> a psychedelic session, butbecomes more acute and easier to sense as <strong>the</strong> session wears on. Thisrapid pulsation may be related to modulatory <strong>in</strong>terrupt and saturation

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