Boreskov

OP‐11threshold is reached the selection regime sharply goes into the random mode generation. Itis important that the critical behavior holds at the level of oligomeric complexity, therefore,the operational precision is required on prebiology, too. For this reason, abiogenicemergence of functional carriers like the "molecular machines", i.e. molecular structurescapable of carrying out precise operations at the molecular level, seems to be an importanttarget of the prebiotic evolution. It should be emphasized that we are talking about theoperational accuracy, but not catalytic activity. From the physical viewpoint, it is fullymeaningless to consider something like the Fox's proteinoids or Oparin's coacervates as thefunctional carriers. On the other hand, native proteins and RNA can hardly be regarded asprebiotic molecular machines, because sophisticated operational systems are needed tofabricate such macromolecules. To find a way, we need the deep insight into the physics ofmolecular machines, the principles of their organizations, the ways of their emergenceunder statistical, not operational, control, as well as the self‐assembly of such functionalcarriers into autonomous operational systems. These are just the issues of modern physicaltrends in the origin of life field (see, for example, [4]), which still are weakly presented in theBOE Program (see, for example, [5]).Two important results relevant for the modern trends will be presented in the talk. Oneis the self‐similarity of fluctuation‐induced protein mobility on anomalously wide range oftime scales up to a dozen of orders [6]. It allows to look at the molecular machine ashierarchically organized scale‐free dynamical system and opens up new ways for designingmolecular machines beyond the proteins and RNAs. Another result relates to a new class ofartificial networks, the random hierarchical networks, with topological properties very closeto the operational systems like the networks of neurons [7]. Again, this finding opens newapproaches to the prebiotic operational networks, as well as to the architecture of earlymetabolism.References[1]. Varfolomeev S. D.Mendeleev Commun. 17, 7 (2007); Varfolomeev S. D. et al. in Problems of the BiosphereOrigin and Evolution, ed. Galimov E. M. (URSS:Moscow, 2008), p.57 (Russian); Dementiev V. A. Ibid p. 79.[2]. Eigen M.et al. J. Phys. Chem. 92, 6881 (1988); Leuthäusser I. J. Stat. Phys. 48, 343 (1987).[3]. Avetisov V. A., Goldanskii V. I., PNAS USA, 93, 11435 (1996); Physics Uspechi, 39, 819 (1996).[4]. Rosen R. Life Itself, Columbia University Press: N.‐Y., 1991, P281.[5]. The Problems of the Origin of Life. Eds. Rozanov A. Yu., Lopatin A. V., Snytnikov V. N. PIN RAN:Moscow,2009 (Russian).[6]. Avetisov V. A., et al. J. Phys. A: Math. Theor., 32, 8785 (1999); 35, 177 (2002); 36, 4239 (2003); Biophys.Rev. and Lett. 3, 387 (2008);[7]. Avetisov V. A. et al. JETP 109, 485 (2009); Physica A 389, 5895 (2010).47