Boreskov

OP‐13We aimed to relate entropy measures of DNA sequences, number of protein‐coding genesand sequence features (GC content) in genome scale for different environment niches of theorganisms under study (Table 1).) 7%0x 6(1t 5nten 4coC 3G/b 2,Me 1size 0moneGFigure 1. Genome size and GCcontent for 1586 prokaryoticgenomes sorted by groups.Axis Y: Average genome size,Mb (bars), and GC – content,% in 10x scale, (cycles). Trendshows correlation betweengenome size and GC content.Genome SizeGC ContentTable 1. Habitat, temperature range, genome size and GC content.Habitat Genome GC Temperature range Genome GC ContentSpecialized 2,767 47,3 Hyperthermophilic 2,084 43,9Host‐associated 3,019 44,9 Thermophilic 2,736 47,9Aquatic 3,893 49,5 Mesophilic 3,909 47,2Multiple 4,561 46,3 Psychrophilic 4,448 43,9Terrestrial 6,674 61,1 Cryophilic 5,223 41N/A 3,689 45,3 N/A 3,761 47,6It is interesting to note, that smaller genome size is associated with specialized habitat,hyperthermophilic temperature and microaerophilic oxygen requirement. In all cases it isrelated to lower GC content.The work is supported in part by RFBR 10‐04‐01310, 11‐04‐01888‐a, SB RAS 119, RASip.26, “Biosph. Ori. Evo. Geo‐Bio. Syst.”References[1]. Koonin E.V. How many genes can make a cell: the minimal‐gene‐set concept. Annu Rev Genomics HumGenet. 2000;1:99‐116.[2]. Mushegian A.R., Koonin E.V. (1996) A minimal gene set for cellular life derived by comparison of completebacterial genomes. Proc Natl Acad Sci U S A 93: 10268–10273.[3]. Gibson D.G., Benders G.A., Andrews‐Pfannkoch C., Denisova E.A., Baden‐Tillson H., et al. (2008) Completechemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science 319: 1215–1220.[4]. Endy D. (2008) Genomics. Reconstruction of the genomes. Science 319: 1196–1197.[5]. Orlov Y.L., Potapov V.N. (2004) Complexity: an internet resource for analysis of DNA sequence complexity.[6]. Nucleic Acids Res. 32(Web Server issue):W628‐33.51