Boreskov

OP‐20PREBIOLOGICAL EVOLUTION OF MACROMOLECULESVarfolomeev S.D., Lushchekina S.V.Institute of Biochemical Physics RAS, Moscow, RussiaThe foundation of life phenomena are (1) significant decrease of the diversity ofmacromolecular structures comparing to the possible repertoire; (2) functionalization ofmacromolecules. In this study the approach describing these observations utilizing the ideaof thermocycle as a driving force of evolution, principles of combinatorial andsupramolecular chemistry is considered. Kinetic models of the process are analyzed andtheir parameters are compared with the true time of prebiological evolution.All natural polymers are products of trifunctional monomers polycondensation generatingpolyamids (aminoacids polycondensation) and polyethers (nucleotide polymerization).The nature of thermocycle is considered. Thermocycle provides thermodynamicalpossibility of polypeptides and polynucleotides formation, including polymization and partialdepolymerization stages. The key question at the stage of macromolecules evolution is asupramolecular interactions of monomers with synthesized polymers. Combinatorial effectsappear as a result of partial disassembling of polymer to monomers due to hydrolyticprocesses under conditions close to liquid‐gas transition.Kinetic processes both in open and closed (the model of evolution in a drop) systems areanalyzed in detail. The general principle of evolution is nonrandom distribution of monomerin polymer chain due to supramolecular interactions; primary synthesized polymers serve asmatrixes for sorbtion and partial selectionof monomers with subsequent polymerization.Due to supramolecular interactions of monomer with polymer, polymer influences theproducts composition.Selection principle and competitive advantage are (1) better thermodynamical stability;(2) better resistance to hydrolytical destruction; (3) uprise of catalytical properties inreactions of peptides, polypeptides, monomers formation aminoacids polymerization,polycondensation of nucleotides. These processes provide transition from pure statistical toevolutionally directed synthesis.An interdependent coexistence of three biopolymers’ ‘universes’ (proteins, RNA andDNA) are considered. In hydrolytical degradation mode in a system peptides and nucleicacids accumulate, they are affine to each other, i.e. form stable supramolecular complexes.In such systems supramolecular complexes is a main selection principle. Processes ofinformation recording and transfer from protein to DNA (hieroglyphic script) are considered.The main principle of the presented study is quantitate calculation of different kineticmodels.63