Boreskov

OP‐29COMPUTER TOOL FOR MODELING THE EUKARYOTES ORIGINAND EVOLUTION OF EARLY EUKARYOTIC ECOSYSTEMSLashin S.A., Suslov V.V., Matushkin Yu.G.Institute of Cytology and Genetics SB RAS; Lavrent’ev ave. 10; Novosibirsk, 630090; RussiaNovosibirsk State University; Pirogova str. 2; Novosibirsk, 630090; RussiaThe formation of eukaryotes in the interior of prokaryotic ecosystems was theevolutionary process involved all levels of organization of living matter from genetic andmetabolic to ecocenotic level. A huge amount of mathematical models of various detailnesshad been developed over the past century. At the present moment the development ofmore complex and composite models using past experience becomes the key problem. Thetopicality of such models is caused by rapid growth of production of experimental and fielddata related to all levels of biological organization on one hand, and growth ofcomputational power on another. The first requires more and more powerful tools for dataanalysis and experiment design, while the second affords ground for that.The software platform “Diploid evolutionary constructor” (DEC) has been developed byus for constructing the models of population genetic and evolutionary processes forpolyploid eukaryotic organisms. The multilayer modeling approach previously applied by usfor implementation of haploid evolutionary constructor [1] was served as themethodological basis for DEC. Each layer of a model is represented by its own submodeldescribing a certain hierarchical level of biological organization. Every particularimplementation of a submodel satisfies a set of specifications (requirements) defined bycorresponding layer.We consider the following base layers in DEC: genotype, phenotype, and fitness whichare the parts of individual’s macro‐layer; there are also population and ecosystem layers.An individual’s genotype is modeled as a vector of chromosomes each of which isrepresented as an ordered list of genes. Several various implementations (classes) are usedfor describing genes: there are implementations in the shape of sequence of letters (e.g.nucleotide), numbers, enumerated type element etc. Various values of genes correspond tovarious alleles. Chromosomal genome organization makes possible to model polyploidy,crossover, rearrangements and translocations, duplication and sexual process. Traits whichare coded by genes may be either monogenic or polygenic. Compensable traits are alsoconsidered to describe the realization of hidden reserve, variation, and resistance to79