1. GENERAL PHARMACOLOGY(a)Pharmacology: Definition, History, and its various branches.Drug: Definition and its various sources.(b)(c)Routes of drugs administration: Advantages and disadvantages.Pharmacokinetics: Drug solubility and passage of drug across thebiological membranes. Absorption, distribution, metabolism andelimination of drugs and factors affecting them. Various pharmacokineticparameters including volume of distribution (Vd), clearance (Cl),Biological half life (t1/2β) Bioavailability and various factors affecting it.Dose, Efficacy and potency of drugs. Hypersensitivity and Idiosyncraticreactions, drug tolerance and dependence. Drug interactions. Plasmaprotein binding.(d)Pharmacodynamics: How drugs act? Receptors and their various typeswith special reference to their molecular structures. Cell surface receptors,signal transduction by cell surface receptors, signaling mediated by intracellular receptors, target cell and hyper sensitization, Pharmacologicaleffects not mediated by receptors (for example anesthetics and cathartics)Ion channel, enzymes, carrier proteins Drug receptor interactions andtheories of drug action. Agonist, antagonist, partial agonist, inverseagonist. Receptors internalization and receptors co-localization.Physiological Antagonism, Pharmacological Antagonism (competitive andnoncompetitive), Neutralization Antagonism, Neurotransmission andneuro-modulation. Specificity of drug action and Factors modifying theaction & dosage of drugs. Median lethal dose (LD:50), Median effectivedose (ED:50) and Therapeutic Index, Dose-response relationships2. DRUGS ACTING ON AUTONOMIC NERVOUS SYSTEM (ANS)a. Organization of ANS its subdivisions and innervations.b. Neurotransmitters in ANS, their synthesis, release and fate.c. Sympathetic agonist drugs: Catecholamines and Noncatecholamines.d. Sympathetic antagonist drugs: Adrenergic receptor Blockers and neuronblockers.e. Parasympathetic (Cholinergic) agonists and Anticholinestrase inhibitors.118 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
Parasympathetic antagonists.f. Ganglion stimulants and Ganglion blockersg. Neuromuscular Blockers3. DRUGS ACTING ON GASTROINTESTINAL TRACT:a. Emetic and anti-emetics.b. Purgativesc. Anti-diarrheal agentsd. Treatment of Peptic ulcer: Antacids, H2-Receptor antagonists,antimuscarinic agents, proton pump inhibitors, prostaglandin agonists, gastrinreceptor antagonist and cytoprotective agents.e. Drug treatment of chronic inflammatory bowel diseases.f. Drugs affecting bile flow and Cholelithiasis4. AUTACOIDS AND THEIR ANTAGONISTS:Histamine and Anti-histamines,Serotonin and Serotonin Antagonists and other Autocoids.5. DRUGS ACTING ON RESPIRATORY SYSTEM:a. Drugs used for cough (Anti-tussives, Expectorants and Mucolytic Agents).b. Drugs used for Bronchial Asthma (Bronchodilators, Cromoglycate, Nedocromil,Cortecosteroids & other Anti-inflammatory drugs and Muscarinic receptorantagonists)6. DRUGS ACTING ON CARDIO-VESCULAR SYSTEM:a. Angina pectorus and its drug treatmentb. Congestive heart failure & its treatment Anti-arrhythmic drugsc. Agents used in Hyperlipidemiad. Coagulants and Anti-coagulantse. Anti-hypertensivesf. Diuretics7. DRUGS ACTING ON GENITOURINARY SYSTEM: Oxytoxic drugs, Ergotalkaloids and uterine relaxants119 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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NATIONAL CURRICULUM REVISIONCOMMITT
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The aims and objectives of Doctor o
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14. To prepare pharmacy graduates f
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and its Applications in Pharmacy)[L
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DETAILS OF COURSES ( SEMESTER SYSTE
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PHARM 311 PHARMACEUTICS-I (Physical
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9. Naser-ud-Din, Introduction to St
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Expression of Genetic Information,
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2. STRUCTURE OF CELL: Cell Membrane
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Communications SkillsObjectives: En
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Experiments to demonstrate some of
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1990.9. Naser-ud-Din, Introduction
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Hemorrhage and Other Causes of Hypo
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IS 402ISLAMIC STUDIESCr. Hr.: 01 Ma
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Publications New Delhi (1989)9) Dr.
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PHARM 413 PHARMACEUTICS-V (Pharmace
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e. Drug treatment of chronic inflam
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j. Labiatae Peppermint, Thyme, Spea
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SECOND SEMESTERPS 403PAKISTAN STUDI
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NOTE:- Practicals of the subject sh
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i. Drugs used for cough (Anti-tussi
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1. Drugs of Animal OriginGeneral in
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Frequency Table, Diagrams, Pictogra
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pharmaceutical students Churchill L
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anaesthetic drugs on human and the
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5. Plant SteroidsIntroduction, extr
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Adenoma, Chondroma, Fibroma, Leomyo
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Aluminium Hydroxide, Ammonium Chlor
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of frog. To demonstrate the effects
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6. Tumor Inhibitors from PlantsIntr
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• Components of a Computer• Com
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1. INTRODUCTION(a) Role of Pharmaci
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3. The Pharmacy Act 1967.4. The Poi
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RecommendationsAll members of NCRC