Download Pharmacy Curriculum Draft (NCRC); 2011

. Factors: persistent, accumulation and loss factorsc. Repetitive Intravenous injections – One Compartment Open Modeld. Repetitive Extravascular dosing – One Compartment Open modele. Multiple Dose Regimen – Two Compartment Open Model2. ELIMINATION OF DRUGS:a) Hepatic Elimination. Percent of Drug Metabolized, DrugBiotransformation reactions, (Phase-I reactions and phase-II reactions),First pass effect, Hepatic clearance of protein bound drugs and Biliaryexcretion of drugs.b) Renal Excretion of Drugs: Renal clearance, Tubular Secretion andTubular Reabsorption.c) Elimination of Drugs through other organs: Pulmonary excretion,Salivary excretion, Mammilary excretion, Skin excretion and Genitalexcretion.6. PROTEIN BINDING: Introduction, types, kinetics, determination andclinical significance of drug-protein binding.4. PHARMACOKINETICS VARIATIONS IN DISEASE STATES.Determination of pharmacokinetics variations in renal and hepatic diseases,general approaches for dose adjustment in renal diseaseand hepatic diseases.5. PHARMACOKINETICS OF INTRAVENOUS INFUSIONS.6. BIOPHARMACEUTICAL ASPECTS INDEVELOPING A DOSAGEFORMDrug considerations, drug product considerations, patient considerations,manufacturing considerations, pharmacodynamic considerationspharmacokinetic considerations7. IN-VITRO-IN-VIVO CORRELATION (IVIVC)Introduction, levels and determination of in-vitro/in-vivo correlationPHARM 627 PHARMACEUTICS-XI (Biopharmaceutics-II) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Blood Sampling Techniques (In Laboratory Animals like dog,rabbits, mice etc. in human beings), In-vitro dissolution studies, Optionaldose determination, Measurement of rate of Bioavailability,Determination of relative and absolute bioavailability. Plasma level-timecurve (Determination of Pharmacokinetic parameters). Determination ofplasma protein binding. Urinary sampling techniques. In Laboratoryanimals. In humans. Renal excretion of drugs or drug disposition.Recommended Books:77 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,