8. A Pryde and M J Gilbert, Applications of High Performance LiquidChromatography, Chapman & Hall, London, 1979.9. E Stahl, Thin Layer Chromatography, 2 nd Ed, Springer-Verlag, Berlin,1969.10. R Hamilton, Introduction to HPLC, P A Sewell, Chapman & Hall, London,1982.HARM 514 PHARMACOLOGY & THERAPEUTICS-III [Th.]Cr. Hr.: 03 Marks: 100Objectives:On completion of this course student should:1. know the aetiology of disease,2. be able to classify the drugs used for its treatment.3. understand the mechanism of drug action4. be able to describe pharmacokinetics, indication, contraindication,dose and dosage, adverse effects, cautions and pre-cautions andtheir interaction with other drugs and food.1. DRUGS ACTING ON CENTRAL NERVOUS SYSTEM(a) Sedatives & Hypnotic(b) Anxiolytics and antidepressants and antimanic drugs(c) Antiepileptics(d) Antiparkinsonian and drug used in other neurodegenerative diseases.(e) Antipsychotics(f) Opioids analgesics(g) Therapeutic gases (Oxygen, Carbon-dioxide, Nitric oxide and Helium.(h) Cerebral Stimulants, Medullary stimulants, Spinal Cord Stimulants.(i) Anesthetics: General and local2. NON STEROIDAL & ANTI-INFLAMMATORY DRUGS, DISEASEMODIFYING DRUGS ANTIRHEUNATIC DRUGS, NON OPIOIDSANALGESICS AND DRUGS USED IN THE TREATMENT OF GOUT.PHARM 515 PHARMACOLOGY & THERAPEUTICS-III [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. To study the convulsant effects of strychnine and picrotoxin in frogsand to determine the site of action. To identify the unknown (convulsant)drug and determine its site of action. To study the effects of Adrenaline onHuman Eyes. To study the effects of Pilocarpine on Human Eyes. Tostudy the effect of Homatropine on Human Eyes. To identify and observethe effects of unknown drugs on Human Eyes. To study the effects of local50 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
anaesthetic drugs on human and the nerve plexus of frog. To identify anddifferentiate the effects of unknown drug on human and the nerve plexusof frog. To demonstrate the effects of Acetylcholine on the Rectusabdominus muscle of frog and competitive pharmacological antagonismby Neuromuscular blocking agent e.g. Gallamine. To identify theunknown drug by performing pharmacological competitive antagonism onRectus abdominus muscle of Frog. To study the anti-coagulant effects ofHeparin and oral anti-coagulants on Rabbits. To identify the unknownanticoagulant drug using Rabbits. To demonstrate the graded Dose-Response curve of Acetylcholine on Rabbit intestine. To identifyunknown concentration of Acetycholine from graded Dose-Responsecurves. To demonstrate the general anesthetic effect on rabbits. Todemonstrate the effect of sedatives and hypnotics on rabbits. Todemonstrate the anti-nociceptive (nalagesic) effect on mice. Todemonstrate antidepressant effect in rats (forced swimming test, tailsuspension test Yohimbin lethality test).(Note: A minimum of 10 practicals should be conducted)Recommended Books:1. Goodman Gilman, Pharmacological basis of therapeutics. 11 thEd,McGraw-Hill Book Company, New York, 2008.2. Winguard and Brody, Human Pharmacology, Mosby Year Book, Boston,1991.3. James M Ritter and Lionel De Levis, A Text book of ClinicalPharmacology, 5 th Ed, Oxford University Press, New York, 2008.4. R S Satorkar and S D Bhandarkar, Pharmacology and Pharmacotherapeutics,Popular Prakashan, Bomby, 1998.5. J D Tripathy, Essential of Medical Pharmacology, Japees Brother, NewDelhi, 6th Ed, 2008.6. D R Laurance, Clinical Pharmacology, ELBS, London, 8th Ed., 1998.7. Katzung B G, Basic and Clinical Pharmacology, McGraw-Hill MedicalPublishers, New York, 11th Ed., 2009.8. Lippincott, Pharmacology, 4th Ed, Lippincott Williams & Wilkins, USA,2008.9. Manuchair Edabi, Pharmacology, Little Brown & Company, London, 1993.10. Prof Dr A Qayum, Fundamentals of Experimental Pharmacology.11. Bertram G K,Basic and Clinical Pharmacology, Paramount PublishingBusiness & Professional Group, USA, 6th Ed., 1995.12. William F Ganong, W F, Review of Medical physiology, 22 nd Ed,2005Prentice Hall International Inc, New Jersey.13. Qayum A, Fundamentals of Experimental Pharmacology. GhandharaUniversity, Peshawar, 2004.14. Pharmacology by Ran & Dell, 6 th edition.51 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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RecommendationsAll members of NCRC