PHARM 718 PHARMACEUTICAL CHEMISTRY-V (Medicinal Chemistry-I) [Th.]Cr. Hr.: 03 Marks: 100Note: The topics will be taught with special reference to their PharmaceuticalApplications.1. INTRODUCTION TO MEDICINAL CHEMISTRY:Chemical constitution and biological activity: (Receptor, Theory, StructureActivity Relationships (SAR) and Drug Metabolism). Modern concept of rationaldrug design, pro drug, combinatorial chemistry and computer aided drug design(CADD) and concept of antisense molecules.2. DRUG TARGETS AND DRUG DESIGNING:i. Introduction and types of Drug targetsii. Introduction to Molecular modeling and computational chemistryiii. Structure based designingiv. Ligand-based designingv. Various techniques in drug synthesis.3. GENERAL PROPERTIES, CHEMISTRY BIOLOGICALACTION,STRUCTURE ACTIVITY RELATIONSHIP ANDTHERAPEUTICAPPLICATIONS OF THE FOLLOWING:a. Hormones: Steroidal Hormones (Testosterone, Progesterone, Estrogen,Aldosteron and Cortisol), Proteinous Hormones (Insulin, Glucagon,Oxytocin and Vassopressin).b. Anti-neoplastic Agents: Tamoxifen, Fluorouracil, Mercapturine,Methotrexate and Vincristine.c. Sedatives,& Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde,Glutethimide, Chloral hydrate, and alcohols.d. Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine,Cocaine and Benzocaine), General anaesthetics (Cyclopropane,Halothane, Nitrous oxide, Chloroform, Thiopental Sodium, Ketamine,Methohexital, Thioamylal Sodium, Fantanyl Citrate, Tribromoethanol).e. Analgesics and Antipyretics: Paracetamol, Salicylic acid analogues,Quinolines derivatives, Pyrazolone and Pyrazolodiones, N -arylanthranilic acids, Aryl and heteroaryl acetic acid derivatives.PHARM 719 PHARMACEUTICAL CHEMISTRY-V (Medicinal Chemistry-I)[Lab.]Cr. Hr.: 01 Marks: 5084 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
NOTE:- Practical of the subject shall be designed from time to time on the basis of theabove mentioned theoretical topics and availability of the facilities, e.g.Estimation of functional groups; Carboxylic, Hydroxy, Amino and Nitrogroups; Determination of Molecular weights of Organic Compounds. Synthesisof Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid, 5-Hydroxy-1, 3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid,o-Chloro-benzoic acid. Assay of the Drugs like Sulpha drugs, Aspirin,Paracetamol, Benzyl Penicillin. Inorganic Preparations.(Note: A minimum of 10 practicals will be conducted)Recommended Books1. Martin and Cook, Remington Practice of Pharmaceutical Science, 12 th Ed,MackPublishing Company, USA, 20012. Foye W O, Principles of Medicinal Chemistry, 6 th Ed, Verghese PublisingHouse, Bomby, 2008.3. Tyagi, Textbook of Synthetic Drugs, Anmol Publications, Delhi, 1990.4. Alferd Burger, Medicinal Chemistry, 6 th Ed, Jhon Willey & Sons, New York,2003.5. Block, Roche, Soine and Wilson, Inorganic and Medicinal PharmaceuticalChemistry, Verghese Publishing House, Bombay, 1986.6. Block, Roche, Soine and Wilson. Inorganic and Medicinal PharmaceuticalChemistry, Lee & Febiger, Philadelphia, USA, 1983.SECOND SEMESTERPHARM 720 PHARMACEUTICS-XIV (Pharmaceutical Technology-II) [Th.]Cr. Hr.: 03 Marks: 1001. Novel GIT Drug Delivery System• Oral Osmotic Pumps• Ion-Exchange Controlled DDS• pH – Controlled DDS• Bio/mucoadhesive DDS• Floating DDS2. Drug Carrier System• Liposomes• Niosomes3. Targeted Drug Delivery System• Active Drug Delivery System• Passive Drug Delivery System4. Pharmaceutical Biotechnology85 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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NATIONAL CURRICULUM REVISIONCOMMITT
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14. To prepare pharmacy graduates f
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DETAILS OF COURSES ( SEMESTER SYSTE
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Communications SkillsObjectives: En
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Hemorrhage and Other Causes of Hypo
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IS 402ISLAMIC STUDIESCr. Hr.: 01 Ma
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Publications New Delhi (1989)9) Dr.
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RecommendationsAll members of NCRC