Download Pharmacy Curriculum Draft (NCRC); 2011

GENERAL PROPERTIES, CHEMISTRY BIOLOGICALACTION,STRUCTURE ACTIVITY RELATIONSHIP ANDTHERAPEUTICAPPLICATIONS OF THE FOLLOWING:i. Sulphonamides: Prontosil, sulphanilamide, Sulphapyridine,sulphadimidine, Sulfamethoxazole, Sulfadiazine and Sulfafurazole.ii. Antimalarials: 4-Aminoquinolines, 8-Aminoquinolines, 9-Amino acridines,Biguanides, Pyrimidine analogues, Mefloquine and Cinchoha alkaloids.iii. Diuretics: Mercaptomerin, Meralluride, Thiazides, Sprironolac-tone,Theophylline, Furosemide, Acetazolamide, Ethacrynic acid and Triameterene.iv. Antitubercular Drugs: Ethambutol, Isonicotinic acid, Hydrazid, Rifampacin,Thioguanine, Pyrazinamide, cycloserine, Ethunamide, Cytarabine, 5-Flourouracil and Dacarbazine.v. Antiviral Drugs: Acyclovir, Tromantadine Hydrochloride and Ribavirin.vi. Immunosuppressant Agents: Azathioprine and Cyclosporin.vii. Antibiotics:Penicillins, Cephalosporins, Streptomycin, Chloramphenicol,Tetracyclines, Kanamycin and Erythromycin.PHARM 729 PHARMACEUTICAL CHEMISTRY-VI (Medicinal Chemistry-II)[Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis of theabove mentioned theoretical topics and availability of the facilities, e.g.Estimation of functional groups; Carboxylic, Hydroxy, Amino and Nitrogroups; Determination of Molecular weights of Organic Compounds. Synthesisof Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid, 5-Hydroxy-1, 3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid,o-Chloro-benzoic acid. Assay of the Drugs like Sulpha drugs, Aspirin,Paracetamol, Benzyl Penicillin. Inorganic Preparations.(Note: A minimum of 10 practicals will be conducted)Recommended Books:1. Martin and Cook, Remington Practice of Pharmaceutical Science, 12 thEd,Mack Publishing Company, USA, 20012. Foye W O, Principles of Medicinal Chemistry, 6 th Ed, Verghese PublisingHouse, Bomby, 2008.3. Tyagi, Textbook of Synthetic Drugs, Anmol Publications, Delhi, 1990.4. Alferd Burger, Medicinal Chemistry, 6 th Ed, Jhon Willey & Sons, New York,2003.5. Block, Roche, Soine and Wilson, Inorganic and Medicinal PharmaceuticalChemistry, Verghese Publishing House, Bombay, 1986.90 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,