DETAILS OF COURSES (ANNUAL SYSTEM)FIRST PROFESSIONALPHARMACEUTICAL CHEMISTRY-I (ORGANIC) WRITTENPaper 1100 MarksNote: The topics will be taught with special reference to theirPharmaceutical Applications.1. BASIC CONCEPTS: Conjugation, hyperconjugation, steric effect, inductive effect,mesomeric effect, hydrogen bonding, Theory of resonance. Effect of structure on reactivity ofcompounds. Tautamerism of carbonyl compounds.2. NUCLEOPHILICAND ELECTROPHILICSUBSTITUTIONREACTION IN ALIPHATICAND AROMATIC SYSTEMS.3. ORIENTATION IN ELECTROPHILIC SUBSTITUTIONREACTIONS ON BENZENERING.4. STUDY OF INDIVIDUAL REACTIONS AND REARRANGEMENTSa) Arndt Eister reaction, Baeyer-Villiger oxidation; Diels Alder reaction; Grignard'sreaction, Metal hydride reduction, Wolf Krishner reduction, Friedel Craft’s reaction, MannichReaction and Condensation reactionb) Pinacol-pinacolone Rearrangement, Hofmann and Beckmann rearrangement, ClaisenRearrangement and Benzilic Acid Rearrangement5. STEREOCHEMISTRY: Stereoisomerism, optical isomerism; Molecules with more than onechiral centre. Geometrical isomerism, Resolution of racemic mixture, Conformationalanalysis.6. FREE RADICALS: Introduction, structure and stability, preparation and properties.7. GENERAL METHODS OF PREPARATIONS, PROPERTIES,IDENTIFICATION TESTAND PHARMACEUTICAL APPLICATIONS OF THE FOLLOWING CLASSES ANDTHEIRANALOGUES: Alcohols, Phenols, Ethers, Aldehydes, Ketones, Acids, esters, Amines.8. PREPARATION AND PROPERTIES OF MEDICINALLYIMPORTANT HETEROCYCLICCOMPOUNDS such as: Pyrrol, Furan, Thiophene, Pyridine96 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
9. PREPARATION AND PROPERTIES OF HETEROCYCLICCOMPOUNDS in which benzoringis fused with five and six member ring containing one heteroatom; Indole, Quinoline andIsoquinoline.PHARMACEUTICAL CHEMISTRY-I (ORGANIC) PRACTICALPaper 8100 MarksNOTE: - Practicals of the subject shall be designed from time to time on the basis of theabove mentioned theoretical topics and availability of the facilities, e.g.1. Organic analysis: Identification of unknown simple organic compounds.2. Organic Preparations: Benzoic acid, Aspirin, Acetanilide, Iodoform,Nitrophenol, 3-nitrophthalic acid, Benzhydrol and 2,4-Dinitrochlorobenzene.Recommended Books1. Peter Sykes, A guide Book to Mechanism in Organic Chemistry, Longman,New York, 6 th Ed, 1991.2. E L Eliel, Stereochemistry of Carbon Compounds, Tata McGraw- Hill, NewDelhi, 1992.3. Rehman and M Younis, Organic Chemistry for B.Sc. students, Ilmi KitabKhana, Lahore, 1997.4. L Finar, Organic Chemistry Vol I, Person Education Asia, 6th Ed., New Delhi,2001.5. Raj K Bansel, Organic Reaction Mechanism, Tata McGraw-Hill, New Delhi,1992.6. Furaiss Brian, Practical Organic Chemistry, 5th Ed., ELBS, London.7. Sykes A P, Guide Book to Mechanism in Organic Chemistry, 6th Ed., LonsmenCo, UK, 2008.8. Roberts J D and Caserio M C, Basic Principles of organic Chemistry, 1990.9. Naser-ud-Din, Introduction to Stereochemistry, Ghafoor Stationery Mart, Peshawar,1994.10. Bhal B S, Textbook of Organic Chemistry, S Chand & Co, New Delhi, 16 th Ed., 2007.11. L.G. Wade, Organic Chemistry, Prentice Hall, New York, U.S.A., 7 th Ed., 2010.97 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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NATIONAL CURRICULUM REVISIONCOMMITT
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DETAILS OF COURSES ( SEMESTER SYSTE
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Communications SkillsObjectives: En
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Hemorrhage and Other Causes of Hypo
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IS 402ISLAMIC STUDIESCr. Hr.: 01 Ma
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Publications New Delhi (1989)9) Dr.
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SECOND SEMESTERPS 403PAKISTAN STUDI
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RecommendationsAll members of NCRC
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