WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 1051238217-55-4Heavy chain / Chaîne lourde / Cadena pesadaQVQLQESGPG LVKPSETLSL TCTVSGFSLT NYGIHWIRQP PGKGLEWLGV 50IWARGFTNYN SALMSRLTIS KDNSKNQVSL KLSSVTAADT AVYYCARAND 100GVYYAMDYWG QGTLVTVSSA STKGPSVFPL APCSRSTSES TAALGCLVKD 150YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTKTY 200TCNVDHKPSN TKVDKRVESK YGPPCPSCPA PEFLGGPSVF LFPPKPKDTL <strong>25</strong>0MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR 300VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL 350PPSQEEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD 400GSFFLYSRLT VDKSRWQEGN VFSCSVMHEA LHNHYTQKSL SLSLGK 446Light chain / Chaîne légère / Cadena ligeraDFVMTQSPAF LSVTPGEKVT ITCSAQSSVN YIHWYQQKPD QAPKKLIYDT 50SKLASGVPSR FSGSGSGTDY TFTISSLEAE DAATYYCQQW TTNPLTFGQG 100TKVEIKRTVA APSVFIFPPS DEQLKSGTAS VVCLLNNFYP REAKVQWKVD 150NALQSGNSQE SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL 200SSPVTKSFNR GEC 213Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-95 146-202 260-320 366-42422''-95'' 146''-202'' 260''-320'' 366''-424''Intra-L 23'-87' 133'-193'23'''-87''' 133'''-193'''Inter-H-L 133-213' 133''-213'''Inter-H-H 2<strong>25</strong>-2<strong>25</strong>'' 228-228''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación296, 296''199
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