WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 105ganetespibumganetespibganétespibganetespib5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-oneantineoplastic5-[2,4-dihydroxy-5-(propan-2-yl)phényl]-4-(1-méthyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-oneantinéoplasique5-[2,4-dihidroxi-5-(propan-2-il)fenil]-4-(1-metil-1H-indol-5-il)-2,4-dihidro-3H-1,2,4-triazol-3-onaantineoplásicoC 20 H 20 N 4 O 3 888216-<strong>25</strong>-9H 3 CNOH 3 CCH 3NNHNHOOHindatuximabum ravtansinum #indatuximab ravtansineindatuximab ravtansineimmunoglobulin G4-kappa, anti-[Homo sapiens SDC1 (syndecan-1,CD138)], chimeric monoclonal antibody conjugated to maytansinoidDM4;gamma4 heavy chain (1-449) [Mus musculus VH (IGHV1-9*01 -(IGHD)-IGHJ4*01) [8.8.15] (1-122) -Homo sapiens IGHG4*01 (123-449)], (136-214')-disulfide with kappa light chain (1'-214') [Musmusculus V-KAPPA (IGKV10-94*01 -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01 (108'-214')]; (228-228'':231-231'')-bisdisulfide dimer; conjugated, on an average of 3 to 4 lysyl, tomaytansinoid DM4 [N 2' -deacetyl-N 2' -(4-mercapto-4-methyl-1-oxopentyl)-maytansine] via the reducible SPDB linker[N-succinimidyl 4-(2-pyridyldithio)butanoate]For the ravtansine part, please refer to the document "INN forpharmaceutical substances: Names for radicals, groups and others"*immunomodulator, antineoplasticimmunoglobuline G4-kappa, anti-[Homo sapiens SDC1 (syndecan-1,CD138)], anticorps monoclonal chimérique conjugué aumaytansinoïde DM4;chaîne lourde gamma4 (1-449) [Mus musculus VH (IGHV1-9*01 -(IGHD)-IGHJ4*01) [8.8.15] (1-122) -Homo sapiens IGHG4*01 (123-449)], (136-214')-disulfure avec la chaîne légère kappa (1'-214')[Mus musculus V-KAPPA (IGKV10-94*01 -IGKJ1*01) [6.3.9] (1'-107')-Homo sapiens IGKC*01 (108'-214')]; dimère (228-228":231-231")-bisdisulfure; conjugué, sur 3 à 4 lysyl en moyenne, aumaytansinoïde DM4 [N 2' -déacétyl-N 2' -(4-mercapto-4-méthyl-1-oxopentyl)-maytansine] via le linker SPDB réductible[4-(2-pyridyldithio)butanoate de N-succinimidyle]Pour la partie ravtansine, veuillez vous référer au document "INN forpharmaceutical substances: Names for radicals, groups andothers"*.immunomodulateur, antinéoplasique173
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