WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 1051188275-92-4Heavy chain / Chaîne lourde / Cadena pesadaEVQLVESGGG LVQPGGSLRL SCAASGFTFS SYLMTWVRQA PGKGLEWVAN 50IKQDGSEKYY VDSVKGRFTI SRDNAKNSLN LQMNSLRAED TAVYYCTRDG 100YSSGRHYGMD VWGQGTTVIV SSASTKGPSV FPLAPSSKST SGGTAALGCL 150VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT 200QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP <strong>25</strong>0KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ 300YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE 350PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP 400PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP 450GK 452Light chain / Chaîne légère / Cadena ligeraEIVLTQSPAT LSLSPGERAT LSCRASQSVS RYLAWYQQKP GQAPRLLIYD 50ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWPRTFGQ 100GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200LSSPVTKSFN RGEC 214Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 149-2105 266-326 372-43022''-96'' 149''-205'' 266''-326'' 372''-430''Intra-L 23'-88' 134'-194'23'''-88''' 134'''-194'''Inter-H-L 2<strong>25</strong>-214' 2<strong>25</strong>''-214'''Inter-H-H 231-231'' 234-234''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación302, 302''navarixinumnavarixinnavarixinenavarixina2-hydroxy-N,N-dimethyl-3-[(2-{[(1R)-1-(5-methylfuran-2-yl)propyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]benzamideanti-inflammatory action through the inhibition of cytokine (IL-8)2-hydroxy-N,N-diméthyl-3-[(2-{[(1R)-1-(5-méthylfuran-2-yl)propyl]amino}-3,4-dioxocyclobut-1-én-1-yl)amino]benzamideanti-inflammatoire (inhibiteur de l'interleukine 8)2-hidroxi-N,N-dimetil-3-[(2-{[(1R)-1-(5-metilfuran-2-il)propil]amino}-3,4-dioxociclobut-1-en-1-il)amino]benzamidainhibidor de citokina (interleukina-8) con acción antiinflamatoriaC 21 H 23 N 3 O 5 473727-83-2H 3 COH 3 CHONHONHOHOCH 3NCH3nelociguatumnelociguatnélociguatnelociguatmethyl (4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)carbamateguanylate cyclase activator(4,6-diamino-2-{1-[(2-fluorophényl)méthyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)carbamate de méthyleactivateur de la guanylate cyclase(4,6-diamino-2-{1-[(2-fluorofenil)metil]-1H-pirazolo[3,4-b]piridin-3-il}pirimidin-5-il)carbamato de metiloactivador de la guanilato ciclasa183
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