WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 105C 35 H 46 ClN 5 O 9 S 630420-16-5OO SH 2 CH 3 CH 3 CONHONHH OCH 3OONHHHNCH 3CH 3CH 3HONClOCH 3besifovirumbesifovirbésifovirbesifovir[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]phosphonic acidantiviralacide [({1-[(2-amino-9H-purin-9-yl)méthyl]cyclopropyl}oxy)méthyl]phosphoniqueantiviralácido [({1-[(2-amino-9H-purin-9-il)metil]ciclopropil}oxi)metil]fosfónicoantiviralC 10 H 14 N 5 O 4 P 441785-<strong>25</strong>-7H 2 NNNNNOOPOHOHblosozumabum #blosozumabblosozumabimmunoglobulin G4-kappa, anti-[Homo sapiens SOST (sclerostin)],humanized monoclonal antibody;gamma4 heavy chain (1-444) [humanized VH (Homo sapiensIGHV1-24*01 (85.70%) -(IGHD)-IGHJ4*01 L123>T (113)) [8.8.11] (1-118) -Homo sapiens IGHG4*01 hinge S10>P (226), CH3 K120>del(119-444)], (132-214')-disulfide with kappa light chain (1'-214')[humanized V-KAPPA (Homo sapiens IGKV1-13*02 (84.00%) -IGKJ1*01 Q120>G (100)) [6.3.9] (1'-107') -Homo sapiens IGKC*01(108'-214')]; (224-224":227-227")-bisdisulfide dimerimmunomodulatorimmunoglobuline G4-kappa, anti-[Homo sapiens SOST(sclérostine)], anticorps monoclonal humanisé;chaîne lourde gamma4 (1-444) [VH humanisé (Homo sapiensIGHV1-24*01 (85.70%) -(IGHD)-IGHJ4*01 L123>T (113)) [8.8.11](1-118) -Homo sapiens IGHG4*01 charnière S10>P (226), CH3K120>del (119-444)], (132-214')-disulfure avec la chaîne légèrekappa (1'-214') [V-KAPPA humanisé (Homo sapiens IGKV1-13*02(84.00%) -IGKJ1*01 Q120>G (100)) [6.3.9] (1'-107') -Homo sapiensIGKC*01 (108'-214')]; dimère (224-224":227-227")-bisdisulfureimmunomodulateur155
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