WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 105olcorolimusumolcorolimusolcorolimusolcorolimús(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahydro-11H-23,27-epoxypyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,11,28,29(31H)-tetroneimmunosuppressant(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-1-[(1S,3R,4R)-4-hydroxy-3-méthoxycyclohexyl)propan-2-yl}-10,21-diméthoxy-6,8,12,14,20,26-hexaméthyl-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahydro-11H-23,27-époxypyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,11,28,29(31H)-tétroneimmunosuppresseur(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihidroxi-3-{(1R)-1-[(1S,3R,4R)-4-hidroxi-3-metoxiciclohexil)propan-2-il}-10,21-dimetoxi-6,8,12,14,20,26-hexametil-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahidro-11H-23,27-epoxipirido[2,1-c][1,4]oxaazaciclohentriacontina-1,11,28,29(31H)-tetronainmunosupresorC 51 H 81 NO 12 186752-78-3OHHHH 3 COHHOHON OOHOOHH 3 CCH 3HH OHOHH 3 C H CH 3 OCH 3CH 3HH 3 C HHCH 3H OCH 3ozoralizumabum #ozoralizumabimmunoglobulin single chain VH-VH'-VH, trivalent bispecific anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamilymember 2, TNFSF2, TNFA, TNF-alpha)] VH and anti-[Homo sapiensALB (albumin, human serum albumin, HSA)] VH', humanized Lamaglama monoclonal antibody;scVH-VH'-VH (1-363) [humanized VH (Homo sapiens IGHV3-74*01(88.80%) -(IGHD)-IGHJ1*01 W118>R (105)) [8.8.8] (1-115) - 9-merlinker (tetraglycyl-seryl-triglycyl-seryl) (116-124) -humanized VH'(Homo sapiens IGHV3-23*04 (89.60%) -(IGHD)-IGHJ1*01 W118>S(229), G119>S (230) [8.8.8] (1<strong>25</strong>-239) -9-mer linker (tetraglycylseryl-triglycyl-seryl)(240-248) -humanized VH (Homo sapiensIGHV3-74*01 (88.80%) -(IGHD)-IGHJ1*01 W118>R (353)(249-363)immunomodulator, anti-inflammatory185
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