Proposed INN: List 105 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong>C 19 H 17 FN 8 O 2 6<strong>25</strong>115-52-8NFNNNNH 2HN OCH 3NH 2ONnivocasanumnivocasannivocasannivocasán(5R)-N-[(2S,3S)-2-(fluoromethyl)-2-hydroxy-5-oxooxolan-3-yl]-3-(isoquinolin-1-yl)-5-(propan-2-yl)-4,5-dihydro-1,2-oxazole-5-carboxamidecaspase inhibitor(5R)-N-[(2S,3S)-2-(fluorométhyl)-2-hydroxy-5-oxooxolan-3-yl]-3-(isoquinoléin-1-yl)-5-(propan-2-yl)-4,5-dihydro-1,2-oxazole-5-carboxamideinhibiteur de la caspase(5R)-N-[(2S,3S)-2-(fluorometil)-2-hidroxi-5-oxooxolan-3-il]-3-(isoquinolin-1-il)-5-(propan-2-il)-4,5-dihidro-1,2-oxazol-5-carboxamidainhibidor de la caspasaC 21 H 22 FN 3 O 5 908<strong>25</strong>3-63-4ONO ONHN O CH3H OHH 3 CFoclacitinibumoclacitiniboclacitiniboclacitinibN-methyl{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamideantineoplastic (veterinary drug)N-méthyl[trans-4-(méthyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexyl]méthanesulfonamideantinéoplasique (produit vétérinaire)N-metil{trans-4-[metil(7H-pirrolo[2,3-d]pirimidin-4-il)amino]ciclohexil}metanosulfonamidaantineoplásico (medicamento veterinario)C 15 H 23 N 5 O 2 S 1208319-26-9O OH 3 C SNHCH 3NHNNN184
<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong> Proposed INN: List 105olcorolimusumolcorolimusolcorolimusolcorolimús(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahydro-11H-23,27-epoxypyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,11,28,29(31H)-tetroneimmunosuppressant(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-1-[(1S,3R,4R)-4-hydroxy-3-méthoxycyclohexyl)propan-2-yl}-10,21-diméthoxy-6,8,12,14,20,26-hexaméthyl-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahydro-11H-23,27-époxypyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,11,28,29(31H)-tétroneimmunosuppresseur(3S,6S,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihidroxi-3-{(1R)-1-[(1S,3R,4R)-4-hidroxi-3-metoxiciclohexil)propan-2-il}-10,21-dimetoxi-6,8,12,14,20,26-hexametil-3,4,5,6,9,10,12,13,14,21,22,23,24,<strong>25</strong>,26,27,32,33,34,34a-icosahidro-11H-23,27-epoxipirido[2,1-c][1,4]oxaazaciclohentriacontina-1,11,28,29(31H)-tetronainmunosupresorC 51 H 81 NO 12 186752-78-3OHHHH 3 COHHOHON OOHOOHH 3 CCH 3HH OHOHH 3 C H CH 3 OCH 3CH 3HH 3 C HHCH 3H OCH 3ozoralizumabum #ozoralizumabimmunoglobulin single chain VH-VH'-VH, trivalent bispecific anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamilymember 2, TNFSF2, TNFA, TNF-alpha)] VH and anti-[Homo sapiensALB (albumin, human serum albumin, HSA)] VH', humanized Lamaglama monoclonal antibody;scVH-VH'-VH (1-363) [humanized VH (Homo sapiens IGHV3-74*01(88.80%) -(IGHD)-IGHJ1*01 W118>R (105)) [8.8.8] (1-115) - 9-merlinker (tetraglycyl-seryl-triglycyl-seryl) (116-124) -humanized VH'(Homo sapiens IGHV3-23*04 (89.60%) -(IGHD)-IGHJ1*01 W118>S(229), G119>S (230) [8.8.8] (1<strong>25</strong>-239) -9-mer linker (tetraglycylseryl-triglycyl-seryl)(240-248) -humanized VH (Homo sapiensIGHV3-74*01 (88.80%) -(IGHD)-IGHJ1*01 W118>R (353)(249-363)immunomodulator, anti-inflammatory185
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