WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
WHO Drug Information Vol. 25, No. 2, 2011
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Proposed INN: List 105 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong> <strong>Vol</strong>. <strong>25</strong>, <strong>No</strong>. 2, <strong>2011</strong>868747-45-9Heavy chain / Chaîne lourde / Cadena pesadaQVQLVQSGAE VKKPGETVKI SCKASDYTFT YYGMNWVKQA PGQGLKWMGW 50IDTTTGEPTY AQKFQGRIAF SLETSASTAY LQIKSLKSED TATYFCARRG 100PYNWYFDVWG QGTTVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD 150YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY 200ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK <strong>25</strong>0DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS 300TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV 350YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 400DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK 449Light chain / Chaîne légère / Cadena ligeraDIVMTQSPLS VPVTPGEPVS ISCRSSKSLL HSNGNTYLYW FLQRPGQSPQ 50LLIYRMSNLV SGVPDRFSGS GSGTAFTLRI SRVEAEDVGV YYCLQHLEYP 100FTFGPGTKLE LKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK 150VQWKVDNALQ SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE 200VTHQGLSSPV TKSFNRGEC 219Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 146-202 263-323 369-42722''-96'' 146''-202'' 263''-323'' 369''-427''Intra-L 23'-93' 139'-199'23'''-93''' 139'''-199'''Inter-H-L 222-219' 222''-219'''Inter-H-H 228-228'' 231-231''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación299, 299''ceftolozanumceftolozaneceftolozaneceftolozano(6R,7R)-3-[(5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateantibiotic(6R,7R)-3-[(5-amino-4-{[(2-aminoéthyl)carbamoyl]amino}-1-méthyl-1H-pyrazol-2-ium-2-yl)méthyl]-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acétamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ène-2-carboxylateantibiotique(6R,7R)-3-[(5-amino-4-{[(2-aminoetil)carbamoil]amino}-1-metil-1H-pirazol-2-io-2-il)metil]-7-[(2Z)-2-(5-amino-1,2,4-tiadiazol-3-il)-2-{[(2-carboxipropan-2-il)oxo]imino}acetamido]-8-oxo-5-tia-1-azabiciclo[4.2.0]oct-2-eno-2-carboxilatoantibióticoC 23 H 30 N 12 O 8 S 2 689293-68-3NSH 3 CCO 2 HH 3 CON OHNHN ONHCO 2SH 3 CNNONH 2NHNHNH 2H 2 N160