WHO Drug Information Vol. 25, No. 2, 2011

WHO Drug Information Vol. 25, No. 2, 2011 Proposed INN: List 105spriferminum #spriferminsprifermineespriferminaL-methionyl[human fibroblast growth factor 18 (FGF-18, zFGF5)-(1-169)-peptide]fibroblast growth factorL-méthionyl[facteur 18 de croissance du fibroblaste humain (FGF-18,zFGF5)-(1-169)-peptide]facteur de croissance des fibroblastesL-metionil[factor 18 de crecimiento de fibroblastos humanos(FGF-18, zFGF5)-(1-169)-péptido]factor de crecimiento de los fibrobastosC 876 H 1396 N 258 O 256 S 6 890058-52-3MEENVDFRIHV ENQTRARDDV SRKQLRLYQL YSRTSGKHIQ VLGRRISARG 50EDGDKYAQLL VETDTFGSQV RIKGKETEFY LCMNRKGKLV GKPDGTSKEC 100VFIEKVLENN YTALMSAKYS GWYVGFTKKG RPRKGPKTRE NQQDVHFMKR 150YPKGQPELQK PFKYTTVTK 169Disulfide bridge location / Position du pont disulfure / Posición del puente disulfuro82-100suvorexantumsuvorexantsuvorexantsuvorexant[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanoneorexin receptor antagonist[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-méthyl-1,4-diazépan-1-yl][5-méthyl-2-(2H-1,2,3-triazol-2-yl)phényl]méthanoneantagoniste du récepteur de l'orexine[(7R)-4-(5-cloro-1,3-benzoxazol-2-il)-7-metil-1,4-diazepan-1-il][5-metil-2-(2H-1,2,3-triazol-2-il)fenil]metanonaantagonista del receptor de la orexinaC 23 H 23 ClN 6 O 2 1030377-33-3ClONNCH 3HN ONNNH 3 Ctabalumabum #tabalumabimmunoglobulin G4-kappa, anti-[Homo sapiens TNFSF13B (tumornecrosis factor superfamily member 13B, BAFF, THANK, TALL-1,TALL1, BLYS, BLyS, B cell activating factor, B lymphocytestimulator, CD257)], Homo sapiens monoclonal antibody;gamma4 heavy chain (1-450) [Homo sapiens VH (IGHV4-34*01(100.00%) -(IGHD)-IGHJ4*01) [8.7.17] (1-123) -IGHG4*01 hingeS10>P (231) (124-450)], (137-214')-disulfide with kappa light chain(1'-214') [Homo sapiens V-KAPPA (IGKV3-11*01 (97.90%) -IGKJ1*01) [6.3.9] (1'-107') -IGKC*05 (108'-214')]; (229-229'':232-232'')-bisdisulfide dimerimmunomodulator195