WHO Drug Information Vol. 24, No. 4, 2010
WHO Drug Information Vol. 24, No. 4, 2010
WHO Drug Information Vol. 24, No. 4, 2010
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Proposed INN: List 104 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong>C 27 H 21 F 3 N 8 O 926037-48-1NNNH 3 CNNHOHNNCH 3NCF 3radretumabum #radretumabradrétumabradretumabimmunoglobulin scFv-CH dimer, anti-[Homo sapiens fibronectin extradomain B (ED-B)], Homo sapiens monoclonal antibody fragmentdimer of single chain (scFv) fused with the IGHE CH4;scFv-CH (1-357) [Homo sapiens VH (IGHV3-23*01 (94.90%) -(IGHD)-IGHJ4*01) [8.8.14] (1-116)-12-mer linker (117-128)- Homosapiens V-KAPPA (IGKV3-20*01 (94.80%) -IGKJ1*01) [7.3.9] (129-236)-5-mer linker (237-<strong>24</strong>1)- Homo sapiens IGHE*01 CH4 (<strong>24</strong>2-349)-8-mer linker (350-357)]; (357:357') disulfide dimerantineoplasticimmunoglobuline scFv-CH dimère, anti-[Homo sapiens extradomaine B (ED-B) de la fibronectine], Homo sapiens anticorpsmonoclonal fragment dimère de scFv fusionné au CH4 de l'IGHE;scFv-CH (1-357) [Homo sapiens VH (IGHV3-23*01 (94.90%) -(IGHD)-IGHJ4*01) [8.8.14] (1-116)-12-mer linker (117-128)- Homosapiens V-KAPPA (IGKV3-20*01 (94.80%) -IGKJ1*01) [7.3.9] (129-236)-5-mer linker (237-<strong>24</strong>1)- Homo sapiens IGHE*01 CH4 (<strong>24</strong>2-349)-8-mer linker (350-357)]; dimère (357:357')antinéoplasiqueinmunoglobulina scFv-CH dímero, anti-[Homo sapiens extra dominioB (ED-B) de la fibronectina], fragmento de anticuerpo monoclonal deHomo sapiens dímero de scFv fusionado con el CH4 del IGHE;scFv-CH (1-357) [Homo sapiens VH (IGHV3-23*01 (94.90%) -(IGHD)-IGHJ4*01) [8.8.14] (1-116)-dodecámero de conexión (117-128)- Homo sapiens V-KAPPA (IGKV3-20*01 (94.80%) -IGKJ1*01)[7.3.9] (129-236)-pentámero de conexión (237-<strong>24</strong>1)- Homo sapiensIGHE*01 CH4 (<strong>24</strong>2-349)-octámero de conexión (350-357)]; dímero(357:357') disulfuroantineoplásico1253180812scFv-CH chain / Chaîne scFv-CH / Cadena scFv-CHEVQLLESGGG LVQPGGSLRL SCAASGFTFS SFSMSWVRQA PGKGLEWVSS 50ISGSSGTTYY ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKPF 100PYFDYWGQGT LVTVSSGDGS SGGSGGASEI VLTQSPGTLS LSPGERATLS 150CRASQSVSSS FLAWYQQKPG QAPRLLIYYA SSRATGIPDR FSGSGSGTDF 200TLTISRLEPE DFAVYYCQQT GRIPPTFGQG TKVEIKSGGS GGPRAAPEVY 250AFATPEWPGS RDKRTLACLI QNFMPEDISV QWLHNEVQLP DARHSTTQPR 300KTKGSGFFVF SRLEVTRAEW EQKDEFICRA VHEAASPSQT VQRAVSVNPE 350SSRRGGC 357Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-chain 22-96 151-217 268-32822'-96' 151'-217' 268'-328'Inter-chain 357-357'390
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