WHO Drug Information Vol. 24, No. 4, 2010

Proposed INN: List 104 WHO Drug Information, Vol. 24, No. 4, 2010vesencumabinmunoglobulina G1-kappa, anti-[NRP1 de Homo sapiens(neuropilina 1, NRP, receptor de la isoforma 165 del factor decrecimiento de células endoteliales vasculares, receptor deVEGF165, VEGF165R, CD304) dominio extracelular], anticuerpomonoclonal de Homo sapiens;cadena pesada gamma1 (1-453) [VH de Homo sapiens (IGHV3-23*04 (90.80%) -(IGHD)-IGHJ6*01) [8.8.16] (1-123) -IGHG1*01 CH3D12>E (362), L14>M (364) (124-453)], (226-214')-disulfuro con lacadena ligera kappa (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (89.50%) -IGKJ1*01) [6.3.9] (1'-107') -IGKC*01 (108'-214')];dímero (232-232'':235-235'')-bisdisulfuroantineoplásico1205533-60-3Heavy chain / Chaîne lourde / Cadena pesadaEVQLVESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSQ 50ISPAGGYTNY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCARGE 100LPYYRMSKVM DVWGQGTLVT VSSASTKGPS VFPLAPSSKS TSGGTAALGC 150LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSSLG 200TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP 250PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE 300QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR 350EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT 400PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS 450PGK 453Light chain / Chaîne légère / Cadena ligeraDIQMTQSPSS LSASVGDRVT ITCRASQYFS SYLAWYQQKP GKAPKLLIYG 50ASSRASGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YLGSPPTFGQ 100GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200LSSPVTKSFN RGEC 214Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 150-206 267-327 373-43122''-96'' 150''-206'' 267''-327'' 373''-431''Intra-L 23'-88' 134'-194'23'''-88''' 134'''-194'''Inter-H-L 226-214' 226''-214'''Inter-H-H 232-232'' 235-235''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación303, 303''vidupiprantumvidupiprantvidupiprantvidupiprant{4-[4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylbenzenesulfonamido)phenoxy]-5-chloro-2-fluorophenyl}acetic acidantiasthmaticacide {4-[4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylbenzènesulfonamido)phénoxy]-5-chloro-2-fluorophényl}acétiqueantiasthmatiqueácido {4-[4-(terc-butilcarbamoil)-2-(2-cloro-4-ciclopropilbencenosulfonamido)fenoxi]-5-cloro-2-fluorofenil}acéticoantiasmático400