WHO Drug Information Vol. 24, No. 4, 2010

WHO Drug Information, Vol. 24, No. 4, 2010 Proposed INN: List 1041044758-60-2Heavy chain / Chaîne lourde / Cadena pesadaEVQLVESGGG LVQPGGSLRL SCAASGFFIT NNYWGWVRQA PGKGLEWVGY 50ISYSGSTSYN PSLKSRFTIS RDTSKNTFYL QMNSLRAEDT AVYYCARTGS 100SGYFDFWGQG TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF 150PEPVTVSWNS GALTSGVHTF PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC 200NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT 250LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY 300RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT 350LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS 400DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPG 446Light chain / Chaîne légère / Cadena ligeraDIQMTQSPSS LSASVGDRVT ITCRASESVD DLLHWYQQKP GKAPKLLIKY 50ASQSISGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GNSLPNTFGQ 100GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200LSSPVTKSFN RGEC 214Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-95 144-200 261-321 367-42522''-95'' 144''-200'' 261''-321'' 367''-425''Intra-L 23'-88' 134'-194'23'''-88''' 134'''-194'''Inter-H-L 220-214' 220''-214'''Inter-H-H 226-226'' 229-229''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación297, 297''florbenazinum ( 18 F)florbenazine ( 18 F)florbénazine ( 18 F)florbenazina ( 18 F)(2R,3R,11bR)-9-(3-[ 18 F]fluoropropoxy)-10-methoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-oldiagnostic aid(2R,3R,11bR)-9-(3-[ 18 F]fluoropropoxy)-10-méthoxy-3-(2-méthylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoléin-2-olproduit à usage diagnostique(2R,3R,11bR)-9-(3-[ 18 F]fluoropropoxi)-3-(2-metilpropil)-10-metoxi-1,3,4,6,7,11b-hexahidro-2H-pirido[2,1-a]isoquinolin-2-olagente de diagnósticoC 21 H 32 18 FNO 3 956903-29-0HOHCH 3H 3 COHNHCH 3[ 18 F]O371