Proposed INN: List 104 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong>elsiglutidumelsiglutideelsiglutideelsiglutida[2-glycine(A>G),3-glutamic acid(D>E),8-serine(D>S),10-leucine(M>L),11-serine(N>S),16-alanine(N>A),<strong>24</strong>-alanine(N>A),28-alanine(Q>A)]human glucagon-like peptide 2 (GLP-2) fusion proteinwith hexalysinamideantidiarrhoeal[2-glycine(A>G),3-acide glutamique(D>E),8-sérine(D>S),10-leucine(M>L),11-sérine(N>S),16-alanine(N>A),<strong>24</strong>-alanine(N>A),28-alanine(Q>A)]peptide 2 semblable au glucagon humain (GLP-2)protéine de fusion avec l’hexalysinamideantidiarrhéique[2-glicina(A>G),3-acide glutámico(D>E), 8-serina(D>S),10-leucina(M>L),11-serina(N>S),16-alanina(N>A),<strong>24</strong>-alanina(N>A),28-alanina(Q>A)]péptido 2 similar al glucagón humano(GLP-2) proteínade fusión con hexalisinamidaantidiarréicoC 196 H 323 N 53 O 56 914009-84-0HGEGSFSSEL STILDALAAR DFIAWLIATK ITDKKKKKK 39Modified residue / Résidu modifié / Residuo modificadoK lysinamideempagliflozinumempagliflozinempagliflozineempagliflozina(1S)-1,5-anhydro-1-C-{4-chloro-3-[(4-{[(3S)-oxan-3-yl]oxy}phenyl)methyl]phenyl}-D-glucitolantidiabetic(1S)-1,5-anhydro-1-C-{4-chloro-3-[(4-{[(3S)-oxan-3-yl]oxy]}phényl)méthyl]phényl}-D-glucitolantidiabétique(1S)-1,5-anhidro-1-C-{4-cloro-3-[(4-{[(3S)-oxan-3-il]oxi}fenil)metil]fenil}-D-glucitolhipoglucemianteC 23 H 27 ClO 7 864070-44-0HOOClHOHOOHOOH366
<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong> Proposed INN: List 104enavatuzumabum #enavatuzumabénavatuzumabenavatuzumabimmunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF12A (tumornecrosis factor receptor superfamily member 12A, fibroblast growthfactor (FGF)-inducible 14 kDa protein, Fn14, TNF-like weak inducerof apoptosis (Tweak) receptor, Tweak receptor, TweakR, CD266],humanized monoclonal antibody;gamma1 heavy chain (1-449) [humanized VH (Homo sapiensIGHV3-7*01 (86.70%) -(IGHD)-IGHJ6*01 T123>L (114)) [8.10.10] (1-119) -Homo sapiens IGHG1*01 CH3 D12>E (358), L14>M (360)(120-449)], (222-218')-disulfide with kappa light chain (1'-218')[humanized V-KAPPA (Homo sapiens IGKV1-39*01 (84.80%) -IGKJ4*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01 (112'-218')];(228-228":231-231")-bisdisulfide dimerantineoplasticimmunoglobuline G1-kappa, anti-[Homo sapiens TNFRSF12A(membre 12A de la superfamille des récepteurs du facteur denécrose tumorale, protéine de 14 kDa induite par le facteur decroissance du fibroblaste (FGF), Fn14, TNF-like faible inducteurd'apoptose (Tweak), récepteur de Tweak, CD266], anticorpsmonoclonal humanisé;chaîne lourde gamma1 (1-449) [VH humanisé (Homo sapiensIGHV3-7*01 (86.70%) -(IGHD)-IGHJ6*01 T123>L (114)) [8.10.10] (1-119) -Homo sapiens IGHG1*01 CH3 D12>E (358), L14>M (360)(120-449)], (222-218')-disulfure avec la chaîne légère kappa (1'-218')[V-KAPPA humanisé (Homo sapiens IGKV1-39*01 (84.80%) -IGKJ4*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01 (112'-218')];dimère (228-228":231-231")-bisdisulfureantinéoplasiqueinmunoglobulina G1-kappa, anti-[TNFRSF12A de Homo sapiens(miembro 12A de la superfamilia de receptores del factor denecrosis tumoral, proteína de 14 kDa inducida por el factor decrecimiento de fibroblastos (FGF), Fn14, TNF-like débil inductor deapoptosis (Tweak), receptor de Tweak, CD266], anticuerpomonoclonal humanizado;cadena pesada gamma1 (1-449) [VH humanizada (Homo sapiensIGHV3-7*01 (86.70%) -(IGHD)-IGHJ6*01 T123>L (114)) [8.10.10] (1-119) -Homo sapiens IGHG1*01 CH3 D12>E (358), L14>M (360)(120-449)], (222-218')-disulfuro con la cadena ligera kappa (1'-218')[V-KAPPA humanizada (Homo sapiens IGKV1-39*01 (84.80%) -IGKJ4*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01 (112'-218')];dímero (228-228":231-231")-bisdisulfuroantineoplásico367
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