Proposed INN: List 104 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong>icrucumabinmunoglobulina G1 kappa, anti-[Homo sapiens FLT1 (tirosin kinasa1 emparentada con el fms, receptor 1 del factor de crecimientoendotelial vascular, VEGFR-1, VEGFR, FLT, FRT, receptor delfactor de permeabilidad vascular)], anticuerpo monoclonal de Homosapiens;cadena pesada gamma1 (1-456) [Homo sapiens VH (IGHV3-33*01(93.90%) -(IGHD)-IGHJ6*01 [8.8.19] (1-126) -IGHG1*03 (127-456)],(229-215')-disulfuro con la cadena ligera kappa (1'-215') [Homosapiens V-KAPPA (IGKV3-20*01 (100.00%) -IGKJ4*01) [7.3.9] (1'-108') -IGKC1*01 (109'-215')]; dímero (235-235'':238-238'')-bisdisulfuroantineoplásico10<strong>24</strong>603-92-6Heavy chain / Chaîne lourde / Cadena pesadaQAQVVESGGG VVQSGRSLRL SCAASGFAFS SYGMHWVRQA PGKGLEWVAV 50IWYDGSNKYY ADSVRGRFTI SRDNSENTLY LQMNSLRAED TAVYYCARDH 100YGSGVHHYFY YGLDVWGQGT TVTVSSASTK GPSVFPLAPS SKSTSGGTAA 150LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS 200SLGTQTYICN VNHKPSNTKV DKRVEPKSCD KTHTCPPCPA PELLGGPSVF 250LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP 300REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG 350QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY 400KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL 450SLSPGK 456Light chain / Chaîne légère / Cadena ligeraEIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY 50GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPLTFG 100GGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK 150VDNALQSGNS QESVTEQDSK DSTYSLSSTL TLSKADYEKH KVYACEVTHQ 200GLSSPVTKSF NRGEC 215Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 153-209 270-330 376-43422''-96'' 153''-209'' 270''-330'' 376''-434''Intra-L 23'-89' 135'-195'23'''-89''' 135'''-195'''Inter-H-L 229-215' 229''-215'''Inter-H-H 235-235'' 238-238''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación306, 306''irosustatumirosustatirosustatirosustat6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamateantineoplasticsulfamate de 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromèn-3-yleantinéoplasiquesulfamato de 6-oxo-6,7,8,9,10,11-hexahidrociclohepta[c]cromen-3-iloantineoplásicoC 14 H 15 NO 5 S 288628-05-7OSNH 2OOOO376
<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong> Proposed INN: List 104ivacaftorumivacaftorivacaftorivacaftorN-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamideCFTR (Cystic fibrosis Transmembrane Regulator) channel activatorN-[2,4-di-tert-butyl-5-hydroxyphényl]-4-oxo-1,4-dihydroquinoléine-3-carboxamideactivateur de la protéine régulatrice de la perméabilitétransmembrainre impliquée dans la mucoviscidoseN-(2,4-di-terc-butil-5-hidroxifenil)-4-oxo-1,4-dihidroquinolina-3-carboxamidaactivateur del canal CFTR (regulador de la conductanciatransmembrana de la fibrosis quística)C <strong>24</strong> H 28 N 2 O 3 873054-44-5HNOOH 3 CHNCH 3CH 3CH 3CH 3OHCH 3ixazomibumixazomibixazomibixazomib{(1R)-1-[(2,5-dichlorobenzamido)acetamido]-3-methylbutyl}boronicacidantineoplasticacide [(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-méthylbutyl]boroniqueantinéoplasiqueacido {(1R)-1-[(2,5-diclorobenzamido)acetamido]-3-metilbutil]borónicoantineoplásicoC 14 H 19 BCl 2 N 2 O 4 1072833-77-2ClOClNHOOHHN BOHHCH3CH 3lenvatinibumlenvatiniblenvatinib4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideantineoplastic4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phénoxy}-7-méthoxyquinoléine-6-carboxamideantinéoplasique377
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