WHO Drug Information Vol. 24, No. 4, 2010

WHO Drug Information, Vol. 24, No. 4, 2010 Proposed INN: List 104plecanatidumplecanatideplécanatideplecanatida[3-glutamic acid(D>E)]human uroguanylin (UGN)gastrointestinal agent[3-acide glutamique(D>E)]uroguanyline humaine (UGN)agent gastro-intestinal[3-ácido glutámico(D>E)]uroguanilina humana (UGN)agente gastrointestinalC 65 H 104 N 18 O 26 S 4 467426-54-6NDECELCVNV ACTGCL 16Disulfide bridges location / Position des ponts disulfure/ Posiciones de los puentes disulfuros4-12 7-15pomaglumetadum methionilumpomaglumetad methionilpomaglumétad méthionilpomaglumetad metionilo(1R,4S,5S,6S)-4-(L-methionylamino)-2,2-dioxo-2λ 6 -thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acidantipsychoticacide (1R,4S,5S,6S)-4-(L-méthionylamino)-2,2-dioxo-2λ 6 -thiabicyclo[3.1.0]hexane-4,6-dicarboxyliqueantipsychotiqueácido (1R,4S,5S,6S)-4-(L-metionilamino)-2,2-dioxo-2λ 6 -tiabiciclo[3.1.0]hexano-4,6-dicarboxílicoantipsicóticoC 12 H 18 N 2 O 7 S 2 635318-55-7H 3 CSHOOSONHNH 2HCO 2 HHHCO 2 Hponatinibumponatinibponatinibponatinib3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideantineoplastic3-[2-(imidazo[1,2-b]pyridazin-3-yl)éthynyl]-4-méthyl-N-{4-[(4-méthylpipérazin-1-yl)méthyl]-3-(trifluorométhyl)phényl}benzamideantinéoplasique3-[2-(imidazo[1,2-b]piridazin-3-il)etinil]-4-metil-N-{4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil}benzamidaantineoplásicoC 29 H 27 F 3 N 6 O 943319-70-8H 3 CHNN CH 3CF 3NNNNO387