WHO Drug Information Vol. 24, No. 4, 2010

WHO Drug Information, Vol. 24, No. 4, 2010 Proposed INN: List 104902141-80-4Heavy chain / Chaîne lourde / Cadena pesadaEVQLVESGGG LVQPGGSLRL SCAASGFTLR SYSMNWVRQA PGKGLEWVSY 50ISRSSHTIFY ADSVKGRFTI SRDNAKNSLY LQMDSLRDED TAMYYCARVY 100SSGWHVSDYF DYWGQGILVT VSSASTKGPS VFPLAPCSRS TSESTAALGC 150LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSNFG 200TQTYTCNVDH KPSNTKVDKT VERKCCVECP PCPAPPVAGP SVFLFPPKPK 250DTLMISRTPE VTCVVVDVSH EDPEVQFNWY VDGVEVHNAK TKPREEQFNS 300TFRVVSVLTV VHQDWLNGKE YKCKVSNKGL PAPIEKTISK TKGQPREPQV 350YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPML 400DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK 449Light chain / Chaîne légère / Cadena ligeraAIQLTQSPSS LSASVGDRVT ITCRASQGIS SALAWYQQKP GKAPKLLIYD 50ASSLESGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FNSYPLTFGG 100GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200LSSPVTKSFN RGEC 214Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 150-206 263-323 369-42722''-96'' 150''-206'' 263''-323'' 369''-427''Intra-L 23'-88' 134'-194'23'''-88''' 134'''-194'''Inter-H-L 137-214' 137''-214'''Inter-H-H 225-225'' 226-226'' 229-229'' 232-232''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación299, 299''gaxilosumgaxilosegaxilosegaxilosa4-O-β-D-galactopyranosyl-D-xylosediagnostic aid4-O-β-D-galactopyranosyl-D-xyloseproduit à usage diagnostique4-O-β-D-galactopiranosil-D-xilosaagente de diagnosticoC 11 H 20 O 10 14087-31-1HOOOHOHHOOOHOOHOHgevokizumabum #gevokizumab immunoglobulin G2-kappa, anti-[Homo sapiens IL1B (interleukin 1beta, 1L1F2, IL-1B)], humanized monoclonal antibody;gamma2 heavy chain (1-445) [humanized VH (Homo sapiensIGHV2-5*10 (72.70%) -(IGHD)-IGHJ5*01) [10.7.12] (1-120) -Homosapiens IGHG2*02 CH3 K130>del (121-445)], (134-214')-disulfidewith kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiensIGKV1-39*01 (82.10%) -IGKJ1*01 V124>L (104')) [6.3.9] (1'-107') -Homo sapiens IGKC*01 (108'-214')]; (222-222":223-223":226-226":229-229")-tetrakisdisulfide dimerinterleukin-1 β antagonist373