WHO Drug Information Vol. 24, No. 4, 2010

WHO Drug Information, Vol. 24, No. 4, 2010 Proposed INN: List 104C 25 H 22 F 3 N 5 O 4 S 848141-11-7F 3 CH 3 CNN N CH 3OOHNNO OSCH3amatuximabum #amatuximabamatuximabamatuximabimmunoglobulin G1-kappa, anti-[Homo sapiens MSLN (mesothelin,pre-pro-megakaryocyte-potentiating factor, megakaryocytepotentiatingfactor, MPF, CAK1)], chimeric monoclonal antibody;gamma1 heavy chain (1-449) [Mus musculus VH (IGHV1-37*01 -(IGHD)-IGHJ2*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01 (120-449)], (222-213')-disulfide with kappa light chain (1'-213') [Musmusculus V-KAPPA (IGKV4-59*01 -IGKJ4*01) [5.3.9] (1'-106') -Homo sapiens IGKC*01 (107'-213')]; (228-228'':231-231'')-bisdisulfide dimerantineoplasticimmunoglobuline G1-kappa, anti-[Homo sapiens MSLN(mésothéline, facteur de potentialisation du pré-pro-mégacaryocyte,facteur de potentialisation des mégacaryocytes, MPF, CAK1)],anticorps monoclonal chimérique;chaîne lourde gamma1 (1-449) [Mus musculus VH (IGHV1-37*01 -(IGHD)-IGHJ2*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01 (120-449)], (222-213')-disulfure avec la chaîne légère kappa (1'-213')[Mus musculus V-KAPPA (IGKV4-59*01 -IGKJ4*01) [5.3.9] (1'-106')-Homo sapiens IGKC*01 (107'-213')]; dimère (228-228'':231-231'')-bisdisulfureantinéoplasiqueinmunoglobulina G1-kappa, anti-[ MSLN de Homo sapiens(mesotelina, factor de potenciación del pre-pro-megacariocito, factorde potenciación de megacariocitos, MPF, CAK1)], anticuerpomonoclonal quimérico;cadena pesada gamma1 (1-449) [Mus musculus VH (IGHV1-37*01 -(IGHD)-IGHJ2*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01 (120-449)], (222-213')-disulfuro con la cadena ligera kappa (1'-213') [Musmusculus V-KAPPA (IGKV4-59*01 -IGKJ4*01) [5.3.9] (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dímero (228-228'':231-231'')-bisdisulfuroantineoplásico355