Proposed INN: List 104 <strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong>mogamulizumab immunoglobuline G1-kappa, anti-[Homo sapiens CCR4 (récepteur 4de chimiokine (C-C motif), récepteur 4 de chimiokine CC, CCR-4,CKR4, k5-5, CD194)], anticorps monoclonal humanisé;chaîne lourde gamma1 (1-449) [VH humanisé (Homo sapiensIGHV3-21*01 (83.70%) -(IGHD)-IGHJ4*01) [8.8.12] (1-119) -Homosapiens IGHG1*01 (120-449)], (222-219')-disulfure avec la chaînelégère kappa (1'-219') [V-KAPPA humanisé (Homo sapiens IGKV2-29*02 (81.00%) -IGKJ1*01) [11.3.9] (1'-112') -Homo sapiensIGKC*01 (113'-219')]; dimère (228-228":231-231")-bisdisulfureimmunomodulateurmogamulizumabinmunoglobulina G1-kappa, anti-[CCR4 de Homo sapiens (receptor4 de quimiokina (C-C motif), receptor 4 de quimiokina CC, CCR-4,CKR4, k5-5, CD194)], anticuerpo monoclonal humanizado;cadena pesada gamma1 (1-449) [VH humanizada (Homo sapiensIGHV3-21*01 (83.70%) -(IGHD)-IGHJ4*01) [8.8.12] (1-119) -Homosapiens IGHG1*01 (120-449)], (222-219')-disulfuro con la cadenaligera kappa (1'-219') [V-KAPPA humanizada (Homo sapiens IGKV2-29*02 (81.00%) -IGKJ1*01) [11.3.9] (1'-112') -Homo sapiensIGKC*01 (113'-219')]; dímero (228-228":231-231")-bisdisulfuroinmunomodulador1159266-37-1Heavy chain / Chaîne lourde / Cadena pesadaEVQLVESGGD LVQPGRSLRL SCAASGFIFS NYGMSWVRQA PGKGLEWVAT 50ISSASTYSYY PDSVKGRFTI SRDNAKNSLY LQMNSLRVED TALYYCGRHS 100DGNFAFGYWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD 150YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY 200ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK 250DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS 300TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV 350YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 400DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK 449Light chain / Chaîne légère / Cadena ligeraDVLMTQSPLS LPVTPGEPAS ISCRSSRNIV HINGDTYLEW YLQKPGQSPQ 50LLIYKVSNRF SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCFQGSLLP 100WTFGQGTKVE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK 150VQWKVDNALQ SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE 200VTHQGLSSPV TKSFNRGEC 219Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 146-202 263-323 369-42722''-96'' 146''-202'' 263''-323'' 369''-427''Intra-L 23'-93' 139'-199'23'''-93''' 139'''-199'''Inter-H-L 222-219' 222''-219'''Inter-H-H 228-228'' 231-231''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación299, 299''namilumabum #namilumabimmunoglobulin G1-kappa, anti-[Homo sapiens CSF2 (Homosapiens colony stimulating factor 2 (granulocyte-macrophage),granulocyte-macrophage colony stimulating factor, GM-CSF)], Homosapiens monoclonal antibody;gamma1 heavy chain (1-449) [Homo sapiens VH (IGHV1-2*02(89.80%) -(IGHD)-IGHJ4*01 L123>M (114)) [8.8.12] (1-119) -IGHG1*01 (120-449)], (222-214')-disulfide with kappa light chain (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (88.40%) -IGKJ4*01)[6.3.9] (1'-107') -IGKC*01 (108'-214')]; (228-228'':231-231'')-bisdisulfide dimerimmunomodulator382
<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong> Proposed INN: List 104namilumabnamilumabimmunoglobuline G1-kappa, anti-[Homo sapiens CSF2 (Homosapiens facteur 2 stimulant de colonies (granulocyte-macrophage),facteur stimulant des colonies de granulocytes et macrophages, GM-CSF)], Homo sapiens anticorps monoclonal;chaîne lourde gamma1 (1-449) [Homo sapiens VH (IGHV1-2*02(89.80%) -(IGHD)-IGHJ4*01 L123>M (114)) [8.8.12] (1-119) -IGHG1*01 (120-449)], (222-214')-disulfure avec la chaîne légèrekappa (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (88.40%) -IGKJ4*01) [6.3.9] (1'-107') -IGKC*01 (108'-214')]; dimère (228-228'':231-231'')-bisdisulfureimmunomodulateurinmunoglobulina G1-kappa, anti-[CSF2 de Homo sapiens (Homosapiens factor 2 estimulante de colonias (granulocito-macrófago),factor estimulante de colonias de granulocitos y macrófagos, GM-CSF)], anticuerpo monoclonal de Homo sapiens;cadena pesada gamma1 (1-449) [Homo sapiens VH (IGHV1-2*02(89.80%) -(IGHD)-IGHJ4*01 L123>M (114)) [8.8.12] (1-119) -IGHG1*01 (120-449)], (222-214')-disulfuro con la cadena ligerakappa (1'-214') [Homo sapiens V-KAPPA (IGKV1-39*01 (88.40%) -IGKJ4*01) [6.3.9] (1'-107') -IGKC*01 (108'-214')]; dímero (228-228'':231-231'')-bisdisulfuroinmunomodulador1206681-39-1Heavy chain / Chaîne lourde / Cadena pesadaQVQLVQSGAE VKKPGASVKV SCKAFGYPFT DYLLHWVRQA PGQGLEWVGW 50LNPYSGDTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCTRTT 100LISVYFDYWG QGTMVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD 150YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY 200ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK 250DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS 300TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV 350YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL 400DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK 449Light chain / Chaîne légère / Cadena ligeraDIQMTQSPSS VSASVGDRVT IACRASQNIR NILNWYQQRP GKAPQLLIYA 50ASNLQSGVPS RFSGSGSGTD FTLTINSLQP EDFATYYCQQ SYSMPRTFGG 100GTKLEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 150DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG 200LSSPVTKSFN RGEC 214Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-96 146-202 263-323 369-42722''-96'' 146''-202'' 263''-323'' 369''-427''Intra-L 23'-88' 134'-194'23'''-88''' 134'''-194'''Inter-H-L 222-214' 222''-214'''Inter-H-H 228-228'' 231-231''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación299, 299''naronapridumnaronapridenaronapride(3R)-1-azabicyclo[2.2.2]octan-3-yl 6-[(3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl]hexanoatedopamine receptor antagonist6-{(3S,4R)-4-(4-amino-5-chloro-2-méthoxybenzamido)-3-méthoxypipéridin-1-yl}hexanoate de (3R)-1-azabicyclo[2.2.2]oct-3-ylantagoniste des récepteurs dopaminergiques383
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