WHO Drug Information Vol. 24, No. 4, 2010
WHO Drug Information Vol. 24, No. 4, 2010
WHO Drug Information Vol. 24, No. 4, 2010
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<strong>WHO</strong> <strong>Drug</strong> <strong>Information</strong>, <strong>Vol</strong>. <strong>24</strong>, <strong>No</strong>. 4, <strong>2010</strong> Proposed INN: List 104telotristatumtelotristattélotristattelotristat4-(2-amino-6-{(1R -1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl) phenyl])-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-L-phenylalaninetryptophan hydroxylase inhibitor4-(2-amino-6-{(1R)-1-[4-chloro-2-(3-méthyl-1H-pyrazol-1-yl)phényl]-2,2,2-trifluoroéthoxy}pryrimidin-4-yl)-L-phénylalanineinhibiteur de l'hydroxylase du tryptophane4-(2-amino-6-{(1R -1-[4-cloro-2-(3-metil-1H-pirazol-1-il)fenil])-2,2,2-trifluoroetoxi}pirimidin-4-il)-L-fenilalaninainhibidor de la hidroxilasa de triptófanoC 25 H 22 ClF 3 N 6 O 3 1033805-28-5NH 2HCF 3NNOCl N N CH 3HNH 2CO 2 Htregalizumabum #tregalizumabtrégalizumabtregalizumabimmunoglobulin G1-kappa, anti-[Homo sapiens CD4 (T cell surfaceantigen T4/Leu-3, p55)], humanized monoclonal antibody;gamma1 heavy chain (1-454) [humanized VH (Homo sapiensIGHV3-15*06 (77.80%) -(IGHD)-IGHJ5*01) [8.10.15] (1-1<strong>24</strong>) -Homosapiens IGHG1*01 (125-454)], (227-218')-disulfide with kappa lightchain (1'-218') [humanized V-KAPPA (Homo sapiens IGKV4-1*01(80.20%) -IGKJ1*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01(112'-218')]; (233-233":236-236")-bisdisulfide dimerimmunomodulatorimmunoglobuline G1-kappa, anti-[Homo sapiens CD4 (antigène desurface T4/Leu-3 de cellule T, p55)], anticorps monoclonalhumanisé;chaîne lourde gamma1(1-454) [VH humanisé (Homo sapiensIGHV3-15*06 (77.80%) -(IGHD)-IGHJ5*01) [8.10.15] (1-1<strong>24</strong>) -Homosapiens IGHG1*01 (125-454)], (227-218')-disulfure avec la chaînelégère kappa (1'-218') [V-KAPPA humanisé (Homo sapiens IGKV4-1*01 (80.20%) -IGKJ1*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01(112'-218')]; dimère (233-233":236-236")-bisdisulfureimmunomodulateurinmunoglobulina G1-kappa, anti-[CD4 de Homo sapiens (antígenode superficie T4/Leu-3 de célula T, p55)], anticuerpo monoclonalhumanizado;cadena pesada gamma1(1-454) [VH humanizada (Homo sapiensIGHV3-15*06 (77.80%) -(IGHD)-IGHJ5*01) [8.10.15] (1-1<strong>24</strong>) -Homosapiens IGHG1*01 (125-454)], (227-218')-disulfuro con la cadenaligera kappa (1'-218') [V-KAPPA humanizada (Homo sapiens IGKV4-1*01 (80.20%) -IGKJ1*01) [10.3.9] (1'-111') -Homo sapiens IGKC*01(112'-218')]; dimero (233-233":236-236")-bisdisulfuroinmunomodulador395
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