WHO Drug Information Vol. 24, No. 4, 2010

Proposed INN: List 104 WHO Drug Information, Vol. 24, No. 4, 20101207446-68-1Heavy chain / Chaîne lourde / Cadena pesadaEEQLVESGGG LVKPGGSLRL SCAASGFSFS DCRMYWLRQA PGKGLEWIGV 50ISVKSENYGA NYAESVRGRF TISRDDSKNT VYLQMNSLKT EDTAVYYCSA 100SYYRYDVGAW FAYWGQGTLV TVSSASTKGP SVFPLAPSSK STSGGTAALG 150CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV LQSSGLYSLS SVVTVPSSSL 200GTQTYICNVN HKPSNTKVDK KVEPKSCDKT HTCPPCPAPE LLGGPSVFLF 250PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE 300EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP 350REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT 400TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL 450SPGK 454Light chain / Chaîne légère / Cadena ligeraDIVMTQSPDS LAVSLGERAT INCRASKSVS TSGYSYIYWY QQKPGQPPKL 50LIYLASILES GVPDRFSGSG SGTDFTLTIS SLQAEDVAVY YCQHSRELPW 100TFGQGTKVEI KRTVAAPSVF IFPPSDEQLK SGTASVVCLL NNFYPREAKV 150QWKVDNALQS GNSQESVTEQ DSKDSTYSLS STLTLSKADY EKHKVYACEV 200THQGLSSPVT KSFNRGEC 218Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuroIntra-H 22-98 151-207 268-328 374-43222''-98'' 151''-207'' 268''-328'' 374''-432''Intra-L 23'-92' 138'-198'23'''-92''' 138'''-198'''Inter-H-L 227-218' 227''-218'''Inter-H-H 233-233'' 236-236''N-glycosylation sites / Sites de N-glycosylation / Posiciones de N-glicosilación304, 304''turoctocogum alfa #turoctocog alfaturoctocog alfaturoctocog alfahuman coagulation factor VIII-(1-750)-(1638-2332)-peptide,glycosylatedblood coagulation factorfacteur VIII de coagulation humain-(1-750)-(1638-2332)-peptideglycosyléfacteur de coagulation sanguinefactor VIII de coagulación humano-(1-750)-(1638-2332)-péptidoglicosiladofactor de coagulación sanguíneaC 7480 H 11379 N 1999 O 2194 S 68 (peptide) 1192451-26-5ATRRYYLGAV ELSWDYMQSD LGELPVDARF PPRVPKSFPF NTSVVYKKTL 50FVEFTDHLFN IAKPRPPWMG LLGPTIQAEV YDTVVITLKN MASHPVSLHA 100VGVSYWKASE GAEYDDQTSQ REKEDDKVFP GGSHTYVWQV LKENGPMASD 150PLCLTYSYLS HVDLVKDLNS GLIGALLVCR EGSLAKEKTQ TLHKFILLFA 200VFDEGKSWHS ETKNSLMQDR DAASARAWPK MHTVNGYVNR SLPGLIGCHR 250KSVYWHVIGM GTTPEVHSIF LEGHTFLVRN HRQASLEISP ITFLTAQTLL 300MDLGQFLLFC HISSHQHDGM EAYVKVDSCP EEPQLRMKNN EEAEDYDDDL 350TDSEMDVVRF DDDNSPSFIQ IRSVAKKHPK TWVHYIAAEE EDWDYAPLVL 400APDDRSYKSQ YLNNGPQRIG RKYKKVRFMA YTDETFKTRE AIQHESGILG 450PLLYGEVGDT LLIIFKNQAS RPYNIYPHGI TDVRPLYSRR LPKGVKHLKD 500FPILPGEIFK YKWTVTVEDG PTKSDPRCLT RYYSSFVNME RDLASGLIGP 550LLICYKESVD QRGNQIMSDK RNVILFSVFD ENRSWYLTEN IQRFLPNPAG 600VQLEDPEFQA SNIMHSINGY VFDSLQLSVC LHEVAYWYIL SIGAQTDFLS 650VFFSGYTFKH KMVYEDTLTL FPFSGETVFM SMENPGLWIL GCHNSDFRNR 700GMTALLKVSS CDKNTGDYYE DSYEDISAYL LSKNNAIEPR SFSQNSRHPS 750QNPPVLKRHQ REITRTTLQS DQEEIDYDDT ISVEMKKEDF DIYDEDENQS 800PRSFQKKTRH YFIAAVERLW DYGMSSSPHV LRNRAQSGSV PQFKKVVFQE 850FTDGSFTQPL YRGELNEHLG LLGPYIRAEV EDNIMVTFRN QASRPYSFYS 900SLISYEEDQR QGAEPRKNFV KPNETKTYFW KVQHHMAPTK DEFDCKAWAY 950FSDVDLEKDV HSGLIGPLLV CHTNTLNPAH GRQVTVQEFA LFFTIFDETK 1000SWYFTENMER NCRAPCNIQM EDPTFKENYR FHAINGYIMD TLPGLVMAQD 1050QRIRWYLLSM GSNENIHSIH FSGHVFTVRK KEEYKMALYN LYPGVFETVE 1100MLPSKAGIWR VECLIGEHLH AGMSTLFLVY SNKCQTPLGM ASGHIRDFQI 1150TASGQYGQWA PKLARLHYSG SINAWSTKEP FSWIKVDLLA PMIIHGIKTQ 1200GARQKFSSLY ISQFIIMYSL DGKKWQTYRG NSTGTLMVFF GNVDSSGIKH 1250NIFNPPIIAR YIRLHPTHYS IRSTLRMELM GCDLNSCSMP LGMESKAISD 1300AQITASSYFT NMFATWSPSK ARLHLQGRSN AWRPQVNNPK EWLQVDFQKT 1350MKVTGVTTQG VKSLLTSMYV KEFLISSSQD GHQWTLFFQN GKVKVFQGNQ 1400DSFTPVVNSL DPPLLTRYLR IHPQSWVHQI ALRMEVLGCE AQDLY 1445Disulfide bridges location / Position des ponts disulfure / Posiciones de los puentes disulfuro153-179 248-329 528-554 630-711 945-971 1012-1016 1134-1282 1287-1439Sulfated residues (Y) / Résidus sulfatés (Y) / Residuos sulfatados(Y)Tyr-346 Tyr-718 Tyr-719 Tyr-723 Tyr-777 Tyr-793Glycosylation sites (N) / Sites de glycosylation (N) / Posiciones de glicosilación (N)Asn-41 Asn-239 Asn-923 Asn-1231396