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Pulmonology<br />

Specific Associations<br />

Presentation<br />

Recent viral syndrome<br />

Alcoholics<br />

Gastrointestinal symptoms, confusion<br />

Young, healthy patients<br />

Persons present at <strong>the</strong> birth of an<br />

animal<br />

Arizona construction workers<br />

HIV with < 200 CD4 cells<br />

Cause<br />

Staphylococcus<br />

Klebsiella<br />

Legionella<br />

Mycoplasma<br />

Coxiella burnetii<br />

Coccidioidomycosis<br />

Pneumocystis (PCP)<br />

An HIV-positive man comes to <strong>the</strong> emergency department with shortness of<br />

breath and a dry cough. His LDH is elevated and <strong>the</strong> chest x-ray shows bilateral<br />

interstitial infiltrates. His pO 2 is 65. What is <strong>the</strong> next best <strong>step</strong> in management?<br />

a. Sputum induction<br />

b. Respiratory isolation<br />

c. Trimethoprim/sulfamethoxazole and prednisone<br />

d. Pentamidine<br />

e. Bronchoalveolar lavage<br />

VAP is:<br />

••<br />

Fever<br />

••<br />

Hypoxia<br />

••<br />

New infiltrate<br />

••<br />

Increasing secretions<br />

Answer: C. PCP is best managed with trimethoprim/sulfamethoxazole. This has better<br />

efficacy than pentamidine. Bronchoalveolar lavage needs to be done and is <strong>the</strong> most<br />

accurate test, but it is more important to start specific <strong>the</strong>rapy. Steroids are indicated if<br />

<strong>the</strong> pO 2 < 70 or <strong>the</strong> A-a gradient > 35. Sputum induction is not as important as starting<br />

treatment. Also, it is only positive in 50–70 percent of patients.<br />

Tuberculosis (TB)<br />

TB occurs in specific risk groups, such as immigrants, HIV-positive patients,<br />

homeless patients, prisoners, and alcoholics. TB presents with fever, cough,<br />

sputum, weight loss, and night sweats.<br />

Diagnostic Testing<br />

··<br />

Best initial test: Chest x-ray<br />

··<br />

Sputum acid-fast stain and culture should be done to confirm <strong>the</strong> presence<br />

of TB.<br />

131

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