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Neurology<br />

The following symptoms may precede <strong>the</strong> headache:<br />

··<br />

Aura of bright flashing lights<br />

··<br />

Scotomata<br />

··<br />

Abnormal smells<br />

Diagnostic Testing<br />

Head CT or MRI should be done when <strong>the</strong> headache has any of <strong>the</strong> following<br />

characteristics:<br />

··<br />

Sudden and/or severe<br />

··<br />

Onset after age 40<br />

··<br />

Associated with focal neurological findings<br />

Treatment<br />

··<br />

Best initial (abortive) <strong>the</strong>rapy: Sumatriptan or ergotamine.<br />

··<br />

Prophylactic <strong>the</strong>rapy (requires several weeks to take effect):<br />

--<br />

When 4 or more headaches occur per month, <strong>the</strong> patient should receive<br />

prophylactic <strong>the</strong>rapy with beta blockers (propranolol).<br />

--<br />

Alternate prophylactic medications are calcium channel blockers, tricyclic<br />

antidepressants, or SSRIs.<br />

Basic Science Correlate<br />

Mechanism of Triptans<br />

Triptans constrict vessels. Migraine is thought to be vasoconstriction followed<br />

by vasodilation, <strong>the</strong>n pain. Triptans function by reconstricting <strong>the</strong> cerebral<br />

vessels. This is why <strong>the</strong>y are dangerous in hypertension, pregnancy, and<br />

coronary disease. Triptans constrict vessels in <strong>the</strong> heart as well, and can<br />

provoke cardiac ischemia.<br />

Cluster Headache<br />

Cluster headaches are 10 times more frequent in men than in women.<br />

Cluster headaches are exclusively unilateral with redness and tearing of <strong>the</strong><br />

eye and rhinorrhea.<br />

Treatment<br />

··<br />

Best initial (abortive) <strong>the</strong>rapy: Triptans or 100 percent oxygen. Triptans are<br />

generally used because <strong>the</strong>y are easier to give at home. Sumatriptan is used<br />

in <strong>the</strong> same way as with migraine headache. Steroids can also be used.<br />

··<br />

Best initial prophylactic <strong>the</strong>rapy: Calcium channel blockers such as verapamil.<br />

By definition, cluster headaches occur multiple times in a short<br />

period and <strong>the</strong>n resolve. The “cluster” is often over by <strong>the</strong> time prophylactic<br />

<strong>the</strong>rapy has taken effect. Verapamil does prevent cluster headache.<br />

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