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Psychiatry<br />

Substance<br />

Alcohol<br />

Amphetamines,<br />

cocaine<br />

Cannabis<br />

Signs and Symptoms<br />

of Intoxication<br />

Talkative, sullen<br />

gregarious, moody<br />

Euphoria, hypervigilance,<br />

autonomic<br />

hyperactivity, weight<br />

loss, pupil dilatation,<br />

disturbed perception,<br />

stroke, myocardial<br />

infarction<br />

Impaired motor<br />

coordination, impaired<br />

time perception,<br />

social withdrawal,<br />

increased appetite, dry<br />

mouth, tachycardia,<br />

conjunctival redness<br />

Treatment of<br />

Intoxication<br />

Mechanical<br />

ventilation if<br />

severe<br />

Short-term use of<br />

antipsychotics,<br />

benzodiazepines,<br />

inderal, vitamin<br />

C to promote<br />

excretion<br />

Signs and<br />

Symptoms of<br />

Withdrawal<br />

Tremors,<br />

hallucinations,<br />

seizures, delirium<br />

Anxiety, tremors,<br />

headache,<br />

increased<br />

appetite,<br />

depression, risk<br />

of suicide<br />

None None None<br />

Treatment of<br />

Withdrawal<br />

Long-acting<br />

benzo’s<br />

No seizure<br />

prophylaxis<br />

Disulfiram or<br />

naloxone for<br />

adjunct to<br />

supervised<br />

<strong>the</strong>rapy after<br />

acute withdrawal<br />

Antidepressants<br />

(continued next page)<br />

Basic Science Correlate<br />

Cocaine blocks <strong>the</strong> reuptake of norepinephrine serotonin and dopamine,<br />

while amphetamines induce <strong>the</strong> release of dopamine.<br />

525

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