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Hematology<br />

Clotting Factor Deficiencies<br />

Deficiency Factor VIII Factor IX Factor XI Factor XII<br />

Presentation<br />

Joint bleeding or<br />

hematoma in a<br />

male child<br />

Joint bleeding<br />

or hematoma;<br />

Less common<br />

than factor VIII<br />

deficiency<br />

Rare bleeding with<br />

trauma or surgery<br />

No bleeding<br />

Diagnostic Test<br />

Mixing study first,<br />

<strong>the</strong>n specific<br />

factor level<br />

Same Same Same<br />

Treatment<br />

Severe deficiency:<br />

(

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