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Selected Projects 20<strong>16</strong>-<strong>18</strong><br />
Catalyzed cross-coupling reactions using aryl halide<br />
reagents have found a prominent role in synthetic<br />
chemistry. The most <strong>no</strong>table are carbon-carbon<br />
coupling reactions, for which Heck, Negishi and<br />
Suzuki received the Nobel Prize in 2010. Similar<br />
carbon-nitrogen couplings, k<strong>no</strong>wn as Buchwald-<br />
Hartwig aryl-amination reactions, have also found<br />
great utility, with applications in natural product<br />
synthesis, medicinal chemistry, organic materials<br />
chemistry, and catalysis. The catalysts in almost<br />
all cross-coupling reactions are based upon the<br />
precious metal palladium (price: $58,000/kg).<br />
Our lab is currently exploring different routes<br />
for the formation of carbon-nitrogen bonds with<br />
less expensive metals. In the summer of 2017, I<br />
studied one such reaction in detail, analyzing the<br />
mechanism that the reaction follows.<br />
46<br />
Diego Javier-Jiminez
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