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SZENT-GYÖRGYI STUDENTS<br />
DÁVID KURSZÁN JÁSZ<br />
Szeged Scientists Academy, 1 st year<br />
University of Szeged,<br />
Faculty of Medicine, 5 th year<br />
YEAR OF BIRTH:<br />
<strong>19</strong>96<br />
FORMER<br />
SZENT-GYÖRGYI<br />
PUPIL:<br />
yes<br />
SZENT-GYÖRGYI<br />
MENTOR:<br />
Petra Hartmann<br />
SPECIALIZATION:<br />
mitochondrial damage<br />
SECONDARY<br />
SCHOOL:<br />
Radnóti Miklós<br />
Experimental Grammar<br />
School<br />
NAME OF TEACHER:<br />
Sándor Bán<br />
LANGUAGES:<br />
English/intermediate<br />
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH<br />
Our research group has demonstrated for the first time that normoxic methane (CH4)<br />
ventilation protects the tissues by mitigating the effects of an ischemia-reperfusion IR insult<br />
(Boros 2012). These data were validated by independent observers, the anti-inflammatory<br />
and anti-apoptotic properties of CH4-based treatments were repeatedly demonstrated<br />
and the evidences now suggest that CH4 can have biological and/or signaling functions<br />
in vivo in mammals. In the “in vitro” branch of our research project we characterize the<br />
mechanism of action of CH4 in the evolution of hypoxic cell injuries on neonatal rat<br />
cardiomyocytes, with special emphasis on biological membranes, as non-specific targets.<br />
The effects of CH4 on cellular and subcellular components, including mitochondria is<br />
tested on isolated cardiac mitochondria. Complex effects of IR injury focusing on specific<br />
organ functions, is investigated in „in vivo” animal models. Our further aim is to outline a<br />
new CH4-based approach for organ preservation, and to develop a solution supplemented<br />
with biologically active gases to achieve better results in clinically-relevant organ storage<br />
models.<br />
AMBITIONS AND CAREER GOALS<br />
Right after finishing my studies, I will apply to the Ph.D. program of the University of<br />
Szeged. During my Ph.D. studies I would like to acquire international experience. I have<br />
a strong interest in autoimmune diseases and I am considering specializing in pediatrics<br />
after getting the Ph.D. qualification.<br />
HONORS AND PRIZES<br />
20<strong>19</strong> – European Society Of Surgical Research (ESSR) Walter Brendel Award 2 nd place<br />
2017 – SZTE ÁOK TDK Konferencia Molekuláris biológia, Sejtbiológia: 1. díj<br />
2014 – OKTV Biology: 22 nd place<br />
2014 – Dr. Zoltán Árokszállásy Biology Competition: 7 th place<br />
PUBLICATIONS<br />
Varga, G., Ugocsai, M., Hartmann, P., Lajkó, N., Molnár, R., Sűcs, Sz., Jász, D.K., Érces, D.,<br />
Ghyczy, M., Tóth, G. (2017) Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces<br />
colon mucosal damage without causing gastric side effects in a rat model of colitis.<br />
Inflammopharmacology 26(Suppl 5)<br />
Harmann, P., Butt, E., Fehér, Á., Szilágyi, Á.L., Jász, D.K., Balázs, B., Bakonyi, M., Berkó, Sz.,<br />
Erős, G., Boros, M., Horváth, Gy., Varga, E., Csányi, E. (<strong>2018</strong>) Electroporation-enhanced<br />
transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis.<br />
Drug design, Development and Therapy 12:<strong>19</strong>17-<strong>19</strong>3<br />
113
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