SzSA YearBook 2018/19

SZENT-GYÖRGYI STUDENTS
FANNI MAGDOLNA MÁRVÁNYKÖVI
Szeged Scientists Academy, 3 rd year
University of Szeged,
Faculty of Medicine, 4 th year
YEAR OF BIRTH:
1996
FORMER
SZENT-GYÖRGYI
PUPIL:
no
SZENT-GYÖRGYI
MENTOR:
Tamás Csont
JUNIOR MENTOR:
Márta Sárközy
SPECIALIZATION:
biochemistry,
experimental cardiology
SECONDARY
SCHOOL:
BMSZC Petrik Lajos
Secondary School,
Budapest
NAME OF TEACHER:
György Láng
Pálné Golopencza
LANGUAGES:
English/advanced
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH
In developed countries, the leading causes of death are cardiovascular diseases. Several
metabolic diseases including e.g. hyperlipidemia, diabetes mellitus, chronic kidney disease
(CKD) increase the risk for cardiovascular diseases. Recently, we have started to investigate
the mechanisms of cardiac hypertrophy and fibrosis associated with CKD in a rat model.
Furthermore, we investigate ischemic stress adaptation (i.e. ischemic preconditioning and
postconditioning) of the heart in the presence of hypertrophy and fibrosis developed in
CKD. Our aim is to investigate the molecular mechanisms (microRNA, mRNA, downstream
targets, circulating miRNAs) in the development of CKD-associated hypertrophy and
fibrosis. We also would like to test new agents for the prevention of fibrosis and left
ventricular hypertrophy in CKD. Moreover, we hope to understand better the effects of
gender difference on the development of hypertrophy and fibrosis, and ischemic stress
adaptation in CKD.
We set up a CKD model in vivo and we investigate ischemic adaptation ex vivo in our
lab. The techniques used by our lab include transthoracic echocardiography, Langendorff
heart perfusion, measurement of the infarct size by planimetry, histology, standard
biochemical and molecular biology methods (e.g. colorimetric assays, PCR, ELISA, etc.).
AMBITIONS AND CAREER GOALS
In my view, the research is indispensable for medical profession, because the treatments
can be developed by scientific results. Later I would like to gain experience abroad, but for
long term I prefer working at my home country. My aim is to be update and transfer the
newly investigated knowledge into practice and curing.
HONORS AND PRIZES
• 2017 - SZTE ÁOK, TDK Conference, Szeged, 2 nd prize (co-author )
• 2017 - SZTE ÁOK, TDK Conference, Szeged, 3 rd prize
• 2018 - XXIII. Korányi Frigyes Scientific Forum, Budapest, 2 nd prize
• 2018 – TDK Field Study, 1 st
• 2018 – SZTE ÁOK TDK Conference, Szeged, 1 st prize
• 2018 – OMAA Application
• 2019 – XXIV. Korányi Frigyes Scienfic Forum, Budapest, 2 nd prize
PUBLICATIONS
Sárközy, M., Zvara, Á., Gáspár, R., Siska, A., Kővári, B., Szűcs, G., Márványkövi, F., Kovács,
M.G., Bodai, L., Zsindely, N., Pipicz, M., Gömöri, K., Kiss, K., Bencsik, P., Cserni, G., Puskás, L.G.,
Földesi, I., Thum, T., Kahán, Zs., Bátkai, S., Csont, T. (2018) Chronic kidney disease induces
cardiac overexpression of the pro-hypertrophic microRNA-212. Scientific Reports IF:
4,259 (D1)
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