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SZENT-GYÖRGYI JUNIOR MENTORS<br />
VIKTÓRIA VENGLOVECZ<br />
University of Szeged,<br />
Department of Pharmacology and Pharmacotherapy<br />
Address: Dóm tér 12., H-6720 Szeged, Hungary<br />
RESEARCH AREA<br />
Disorders of epithelial ion transport play an important role<br />
in the development of many diseases such as cystic fibrosis<br />
or diarrhea. Recent research has shown that altered ion<br />
transport may also be responsible for the pathomechanism<br />
of pancreatic inflammatory diseases and for the abnormal,<br />
metaplastic changes of the esophagus (Barrett’s<br />
esophagus). The incidence of these diseases is increasing<br />
worldwide, placing a huge and costly burden on health-care<br />
system. At present, the pathomechanism of pancreatitis or<br />
Barrett’s esophagus is not completely understood, which<br />
makes it difficult to develop effective therapies. The aim<br />
of my research work is to examine the role of ion transport<br />
processes in the development and progression of these<br />
gastrointestinal diseases and to identify therapeutic targets<br />
that can be a promising starting point for treating of these<br />
diseases.<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
Isolation of primary pancreatic and esophageal epithelial<br />
cells, establishment of organoid cultures, cell culture.<br />
Confocal and fluorescent microscopy (intracellular pH<br />
and Ca 2+ measurements), functional and morphological<br />
examination of mitochondria, patch clamp technique.<br />
Molecular biological methods such as immunofluorescence<br />
staining, conventional and RT-PCR, Western blot, different<br />
cell assays (proliferation, migration, adhesion, cytotoxicity<br />
assay). Induction of acute and chronic pancreatitis in animal<br />
models, enzyme activity measurements (amylase, trypsin,<br />
myeloperoxidase, lactate dehydrogenase), histological<br />
studies.<br />
SELECTED PUBLICATIONS<br />
Venglovecz, V., Pallagi, P., Kemény, L., Balázs, A., Balla, Zs.,<br />
Becskeházi, E., Gál, E., Tóth, E., Zvara, Á., Puskás, L., Borka, K.,<br />
Sendler, M., Lerch, M.M., Mayerle, J., Kühn, J.P., Rakonczay,<br />
Z. Jr., Hegyi, P. (<strong>2018</strong>) The importance of Aquaporin 1 in<br />
pancreatitis and its relation to the CFTR Cl- channel. Front<br />
Physiol. <strong>2018</strong>;9:854.<br />
Laczkó, D., Rosztóczy, A., Birkás, K., Katona, M., Rakonczay, Z.<br />
Jr., Tiszlavicz, L., Róka, R., Wittmann, T., Hegyi, P., Venglovecz,<br />
V. (2016) Role of ion transporters in the bile acid-induced<br />
esophageal injury. Am J Physiol Gastrointest Liver Physiol.<br />
2016; 311(1):G16-31.<br />
Katona, M., Hegyi, P., Kui, B., Balla, Zs., Rakonczay, Z. Jr.,<br />
Rázga, Zs., Tiszlavicz, L., Maléth, J., Venglovecz, V. (2016) A<br />
novel, protective role of ursodeoxycholate in bile-induced<br />
pancreatic ductal injury. Am J Physiol Gastrointest Liver<br />
Physiol. 2016;310(3):G<strong>19</strong>3-204.<br />
Venglovecz, V., Hegyi, P., Rakonczay, Z. Jr., Tiszlavicz, L.,<br />
Nardi, A., Grunnet, M., Gray, M.A. (2011) Pathophysiological<br />
relevance of apical large-conductance Ca2+-activated<br />
potassium channels in pancreatic duct epithelial cells. Gut<br />
2011;60:361-369.<br />
Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee JS, Kim<br />
KS, Venglovecz V, Gray MA, Kim KH, and Lee MG: Dynamic<br />
regulation of CFTR bicarbonate permeability by [Cl-]i and its<br />
role in pancreatic bicarbonate secretion. Gastroenterology<br />
2010;139(2):620-631.<br />
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