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SZENT-GYÖRGYI STUDENTS<br />
ANNA NÁSZAI<br />
Szeged Scientists Academy, 5 th year<br />
University of Szeged,<br />
Faculty of Medicine, 5 th year<br />
YEAR OF BIRTH:<br />
<strong>19</strong>96<br />
FORMER<br />
SZENT-GYÖRGYI<br />
PUPIL:<br />
no<br />
SZENT-GYÖRGYI<br />
MENTOR:<br />
Mihály Boros<br />
JUNIOR MENTOR:<br />
László Juhász<br />
SPECIALIZATION:<br />
biochemistry, physiology,<br />
pathophysiology<br />
SECONDARY<br />
SCHOOL:<br />
Radnóti Miklós<br />
Experimental Grammar<br />
School, Szeged<br />
NAME OF TEACHER:<br />
Sándor Bán<br />
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH<br />
Tissue hypoperfusion and hypoxia due to circulatory or respiratory insufficiency are usually<br />
severe conditions which are often difficult to treat in the clinical practice. The decrease<br />
in tissue oxygen supply may initiate mitochondrial dysfunction leading to defects of<br />
electron transport, ATP synthesis and calcium homeostasis. As a result of oxido-reductive<br />
stress, intracellular calcium overload may occur which leads to opening of mitochondrial<br />
permeability transition pore (mPTP), non-selective calcium release and apoptosis. Certain<br />
biologically active gases (e.g. nitric oxide) were shown to influence hypoxia-reoxygenation<br />
injuries via mPTP inhibition. Our research project is focused on the effects of methane<br />
inhalation on mitochondrial calcium uptake and release in a rodent model of hypoxemic<br />
hypoxemia.<br />
AMBITIONS AND CAREER GOALS<br />
I hope my research career will eventually amount to a PhD degree, and I would like to live<br />
to see methane used in clinics as a bioactive gas in decreasing IR injuries.<br />
HONORS AND PRIZES<br />
• 2013 - European Union Science Olympiad (EUSO) - gold medal<br />
• 2014 - OKTV Biology, II category, <strong>19</strong> th place<br />
• 2016 - Joint Program for European Medical Studies (JPEMS) scholarship<br />
• 2017 – University of Szeged, Annual Student Research Conference (TDK Conference) –<br />
2 nd place<br />
PUBLICATIONS<br />
Poles, M.Z., Bódi, N., Bagyánszki, M., Fekete, É., Mészáros, A.T., Varga, G., Szűcs, Sz., Nászai,<br />
A., Kiss, L., Kozlov, A.V., Boros, M., Kaszaki, J. (<strong>2018</strong>) Reduction of nitrosative stress by<br />
methane: Neuroprotection through xanthine oxidoreductase inhibition in a rat model of<br />
mesenteric ischemia-reperfusion. Free Radic Biol Med 120: 160-169.<br />
LANGUAGES:<br />
English/advanced<br />
122
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