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SZENT-GYÖRGYI JUNIOR MENTORS<br />
PETRA HARTMANN<br />
University of Szeged,<br />
Institute of Surgical Research<br />
Address: Pulz utca 1., H-6724 Szeged, Hungary<br />
RESEARCH AREA<br />
Previous studies constructed a comprehensive picture on<br />
the biological effects of exogenous methane (CH 4<br />
) in various<br />
ischemia-reperfusion (IR) and inflammatory settings.<br />
However, the underlying mechanisms are still not known<br />
with certainty; and the immediate challenge is therefore to<br />
test hypotheses to understand the background of CH 4<br />
-induced<br />
reactions. Our main purpose is to examine the effects<br />
of CH 4<br />
on possible cellular and subcellular targets, including<br />
mitochondria and to apply CH 4<br />
in complex, in vivo animal<br />
models of IR, focusing on specific organ functions.<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
In vivo animal models (rodents and large animals), in vivo<br />
imaging techniques with fluorescent laser-scanning endomicroscopy<br />
or intravital microscopy. Microcirculatory measurements<br />
with orthogonal polarization spectral imaging<br />
and laser-Doppler. Ex vivo organ perfusion systems (liver,<br />
kidney) for static and dynamic graft preservation. Measurement<br />
of mitochondrial respiration, hydrogen-peroxyde<br />
production and membrane potential using high-resolution<br />
respirometry and its fluorescent moduls (Oxygraph2k). Basic<br />
laboratory techniques (spectrophotometry, isolation of<br />
mitochondria).<br />
SELECTED PUBLICATIONS<br />
Szilágyi, Á.L., Mátrai, P., Hegyi, P., Tuboly, E., Pécz, D., Garami,<br />
A., Solymár, M., Pétervári, E., Balaskó, M., Veres, G., Czopf, L.,<br />
Wobbe, B., Szabó, D., Wagner, J., Hartmann, P. (<strong>2018</strong>) Compared<br />
efficacy of preservation solutions on the outcome of<br />
liver transplantation: Meta-analysis. World J Gastroenterol.<br />
28;24(16):1812-1824.<br />
Mészáros, A.T., Szilágyi, Á.L., Juhász, L., Tuboly, E., Érces, D.,<br />
Varga, G., Hartmann, P. (2017) Mitochondria As Sources and<br />
Targets of Methane. Front Med (Lausanne) 13;4:<strong>19</strong>5<br />
Tuboly, E., Molnár, R., Tőkés, T., Turányi, R.N., Hartmann, P.,<br />
Mészáros, A.T., Strifler, G., Földesi, I., Siska, A., Szabó, A., Mohácsi,<br />
Á., Szabó, G., Boros, M. (2017) Excessive alcohol consumption<br />
induces methane production in humans and rats.<br />
Sci Rep. 4;7(1):7329.<br />
Strifler, G., Tuboly, E., Görbe, A., Boros, M., Pécz, D., Hartmann,<br />
P. (2016) Targeting Mitochondrial Dysfunction with L-Alpha<br />
Glycerylphosphorylcholine. PLoS One. 18;11(11):e0166682.<br />
Strifler, G., Tuboly, E., Szél, E., Kaszonyi, E., Cao, C., Kaszaki, J.,<br />
Mészáros, A., Boros, M., Hartmann, P. (2016) Inhaled Methane<br />
Limits the Mitochondrial Electron Transport Chain<br />
Dysfunction during Experimental Liver Ischemia-Reperfusion<br />
Injury. PLoS One. 7;11(1):e0146363.<br />
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