SZENT-GYÖRGYI MENTORS ”If I go out into nature, into the unknown, to the fringes of knowledge, everything seems mixed up and contradictory, illogical, and incoherent. This is what research does; it smooths out contradictions and makes things simple, logical, and coherent.” Albert Szent-Györgyi Szent-Györgyi Mentors of the Szeged Scientists Academy are researchers, who engage in internationally highly reputable scientific activities, supervise their own research groups, and whose works are published in prestigious scientific journals. Szent-Györgyi Mentors are committed to participate in the education of the Szent-Györgyi Students, offering them the opportunity to join their research groups that provide the required conditions for research. Szent- Györgyi Mentors also personally assist in training and developing the young talents, primarily focusing on the importance of nurturing talent. Szent-Györgyi Mentors also undertake to involve other mentors from among his or her foreign partners in the activities of the Szeged Scientists Academy as Szent-Györgyi International Mentors so as to provide Szent-Györgyi Students with the ability to participate in the projects of foreign laboratories as well. Currently, there are 40 Szent-Györgyi Mentors supporting the Szent- Györgyi Students of the Szeged Scientists Academy. They are renowned and recognised scientists of the University of Szeged and the Biological Research Center of the Hungarian Academy of Sciences, and they are all part of a widespread international network of scientists and researchers. They engage in internationally admired microbiological, genetic and biomedical research.
SZENT-GYÖRGYI MENTORS ZOLTÁN RAKONCZAY PROFESSIONAL LEADER OF THE UNIVERSITY PROGRAM Department of Pathophysiology, University of Szeged Address: Semmelweis u. 1., H-6725 Szeged, Hungary RESEARCH AREA Acute pancreatitis is a sudden inflammation of the pancreas which can have mild or severe course. Unfortunately, the latter form still has an unacceptably high mortality. The reason for this is, at least in part, due to the facts that the pathomechanism of acute pancreatitis is unclear and we have no specific treatment of the disease. The main aims of our group are to investigate the roles of various inflammatory factors, mitochondria and the recently identified pancreatic ductal cells in the development of acute pancreatitis. Our hope is to eventually open up new therapeutic possibilities in acute pancreatitis. TECHNIQUES AVAILABLE IN THE LAB Induction of acute pancreatitis in animals, isolation of pancreatic acinar and ductal cells, measurement of enzyme (amylase, trypsin, myeloperoxidase, lacatate dehydrogenase) activities, confocal microscopy, histological analysis, ELISA, microspectrofluorimetry (intracellular H + , Ca 2+ concentration), microperfusion of pancreatic ducts, measurement of pancreatic ductal fluid secretion, Western blot analysis, RT-PCR. SELECTED PUBLICATIONS Biczó, G., Végh, E.T., Shalbueva, N., Mareninova, O.A., Elperin, J., Lotshaw, E., Gretler, S., Lugea, A., Malla, S.R., Dawson, D., Ruchala, P., Whitelegge, J., French, S.W., Wen, L., Husain, S.Z., Gorelick, F.S., Hegyi, P., Rakonczay Jr., Z., Gukovsky, I., Gukovskaya, A.S. (<strong>2018</strong>) Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology 154: 689-703. Pallagi, P., Hegyi, P., Rakonczay Jr., Z. (2015) The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians. Pancreas 44: 1211-1233. Pallagi, P., Balla, Z., Singh, A.K., Dósa, S., Iványi, B., Kukor, Z., Tóth, A., Riederer, B., Liu, Y.J., Engelhardt, R., Jármay, K., Szabó, A., Janovszky, Á., Perides, G., Venglovecz, V., Maléth, J., Wittmann, T., Takács, T., Gray, M.A., Gácser, A., Hegyi, P., Seidler, U., Rakonczay Jr., Z. (2014) The role of pancreatic ductal secretion in protection against acute pancreatitis in mice. Crit Care Med 42: e177-88. Biczó, G., Hegyi, P., Dósa, S., Shalbuyeva, N., Berczi, S., Sinervirta, R., Hracskó, Z., Siska, A., Kukor, Z., Jármay, K., Venglovecz, V., Varga, I.S., Iványi, B., Alhonen, L., Wittmann, T., Gukovskaya, A., Takács, T., Rakonczay Jr., Z. (2011) The crucial role of early mitochondrial injury in L-lysine-induced acute pancreatitis. Antioxid Redox Signal 15: 2669-81. Rakonczay Jr., Z., Hegyi P., Takács T., McCarroll J., Saluja A.K. (2008) The role of NF-κB activation in the pathogenesis of acute pancreatitis. Gut 57: 259-267. 36