Wellness Foods + Supplements 1/2022

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Functional ingredients in gut health Gut microbiota represents one of the most incriminated components in IBD development. Indeed, in intestinal inflammation, there is a disruption of the harmonious relationship between the microbiota and the immune system. Microbiota becomes unbalanced and immune system overactivated. The unbalanced microbiota, called dys biosis, is characterized by an increase of the “aggressive” species and a impoverishment in the probiotic species 7 . Interestingly, Naticol ® Gut administration consistently decreases the burden of “bad” bacteria and yeast such as Escherichia coli or Candida albicans while it enriches populations of protective bacteria and yeast such as Saccharomyces cerevisiae or Lactobacillus sp. Our study demons trates that this modulation of gut microbiota is exerted through the effect of Naticol ® Gut on the immune system via a crosstalk between both components 6 (Fig. 3). Fig. 2: Cytokine expression by macrophages ##p ≤ 0.01, ###p ≤ 0.005, ####p ≤ 0.001 DSS-exposed mice compared to DSS-exposed mice treated with Naticol ® Gut type (Fig. 2). This effect on macrophages reverberates on the whole immune system as the global pro-inflammatory mediators’ production is significantly dampened by Naticol ® Gut 6 . Naticol ® Gut impacts gut microbiota Fig. 3: microbiota fluctuation #p ≤ 0.05, ##p ≤ 0.01, DSS-exposed mice compared to DSS-exposed mice treated with Naticol ® Gut Conclusion The use of functional ingredients in gut health management is an emerging concept. In this context, Weishardt provides solid preclini cal results as well as an encouraging translational approach using immune cells directly collected from human subjects and in which results show that Naticol ® Gut restores an anti-inflammatory profile. Last but not least, Weishardt has taken the science behind fish collagen peptides to a deeper level of understanding by highlighting the mechanism by which Naticol ® Gut exerts its beneficial effects. References 1 Actis, G. C., Pellicano, R., Fagoonee, S. & Ribaldone, D. G. History of Inflammatory Bowel Diseases. J. Clin. Med. 8, 1970 (2019). 2 Rajendran, N. & Kumar, D. Role of diet in the management of inflammatory bowel disease. World J. Gastroenterol. WJG 16, 1442–1448 (2010). 3 Rossi, R. E. et al. The role of dietary supplements in inflammatory bowel disease: a systematic review. Eur. J. Gastroenterol. Hepatol. 28, 1357–1364 (2016). 4 Kühl, A. A., Erben, U., Kredel, L. I. & Siegmund, B. Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases. Front. Immunol. 6, (2015). 5 Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, 15.25.1-15.25.14 (2014). 6 Rahabi, M. et al. Bioactive fish collagen peptides weaken intestinal inflammation by orienting colonic macrophages phenotype through mannose receptor activation. Eur. J. Nutr. (2022) doi:10.1007/s00394-021-02787-7. 7 Ni, J., Wu, G. D., Albenberg, L. & Tomov, V. T. Gut microbiota and IBD: causation or correlation? Nat. Rev. Gastroenterol. Hepatol. 14, 573–584 (2017). Photo © : Shutterstock/rangizz For more information, please contact WEISHARDT International 81300 Graulhet, France Phone +33 5 63 42 14 41 welcome@weishardt.com www.weishardt.com 10 No. 1 April/May 2022
Connect with nutraceutical experts This year, Vitafoods Europe 2022 returns to its annual May slot in your diary. As it’s a hybrid event you’ll be able to join us in person and online to share ideas, see new products, source ingredients and innovate with an inspiring community of experts. This is your chance to connect with industry-leading buyers, suppliers and manufacturers from over 110 countries, so don’t miss it. Register for your free badge now and save €160* Geneva: 10-12 May Online: 2-13 May For more details visit vitafoods.eu.com *Onsite visitor registration will cost €160
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