Wellness Foods + Supplements 1/2022

Cover story
trophotometric contents – DMAC method)
and contains the full polyphenols profile of
natural cranberry, including flavonols, anthocyanins
and phenolic acids.
A recent human urines pharmacokinetics
study (2) has been done with the aim to
profile, by using an HPLC-MS/MS method,
cranberry compounds and metabolites
found in human urine after supplementation
of a highly standardized cranberry extract:
Anthocran ® Phytosome ® . Two different strategies
were adopted for the data analysis: a
targeted and an untargeted approach. These
strategies allowed the identification of 42
analytes including cranberry components,
known metabolites and metabolites hitherto
unreported in the literature, including eight
valerolactones/valeric acid derivatives whose
presence in urine after cranberry consumption
has never been described before.
Moreover, the ex vivo study showed that urine
fractions rich in these metabolites are the
most active against the pathogen Candida
so frequent in hospitalized patients; it can
reach the 10 % of positive urine cultures in
hospitals, intensive care units and tertiary
care facilities.
To support from a clinical point of view
these interesting data, a pilot registry study
(3) recently investigated the effects of the
oral supplementation of a standardized
Anthocran ® Phytosome ® for the support of
urinary tract health.
reported to have a more favorable actions in managing UTI discomforts
(like urinary frequency, urinary urgency, dysuria and nocturia),
as assessed on the visual analogue scale, compared with subjects in
the standard management or nitrofurantoin groups.
No subjects with blood in urines and with traces of bacterial infection
in urine in the group treated with the supplement compared with
controls (p < 0.05). The cranberry extract was also superior to the
control management in terms of recurrence of signs, with none of the
subjects in this group reporting a R-UTI in the 3-months following the
study end (p < 0.05).
The supplementation showed an optimal safety profile, with no significant
adverse events and no drop-outs in the supplement group.
The study shows that cranberry extract (Anthocran ® formulated as
Phytosome ® ) is a valid diet supplementation for subjects where postoperative,
post-catheter R UTIs may occur, whit a good tolerability
profile.
References
1 World J Urol. 2020 Nov;38(11):2669-2679. doi: 10.1007/s00345-019-03071-4.
Epub 2020 Jan 10.)
2 Giovanna Baron et alii, Biochemical Pharmacology 173 (2020) 113726
3 Roberto Cotellese, Andrea Ledda, Gianni Belcaro, Maria R. Cesarone, Claudia Scipione,
Valeria Scipione, Mark Dugall, Beatrice Feragalli, Antonella Riva, Pietro Allegrini,
Giovanna Petrangolini & Stefano Togni (2021):, DOI: 10.1080/19390211.2021.1972074
For more information, please contact
Laura Bo
External Communication and
Sustainability, Indena S.p.A.
laura.bo@indena.com
www.indena.com
The study included 64 otherwise healthy
subjects who underwent a surgical procedure
and required post-surgical urinary
catheterization. The subjects have been
divided by randomization in four groups:
12 subjects were given supplementation
with the standardized cranberry extract at
the dose of either 120 mg/day, 12 subjects
at 240 mg/day, 18 subjects were assigned
to a control group consisting of standard
management and 22 to a group with nitrofurantoin
administration for four weeks to
relief the R UTIs.
At the end, subjects receiving the standardized
cranberry Phytosome ® supplementation
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