Wellness Foods + Supplements 1/2022

Functional ingredients in gut health
Naticol ® Gut: a key ingredient in gut health
Weishardt patented fish collagen peptides modulate intestinal inflammation
Mouna Rahabi, PhD
Inflammatory bowel diseases (IBD) are chronic inflammatory
diseases affecting the gastrointestinal tract. Remaining
largely unclear, the etiology of IBD involves a complex interaction
between genetics, environmental and microbial
factors and immune responses 1 .
In fact, there is clear evidence that the prevalence of IBD is associated
with the environment as demonstrated by a north-south gradient
of the disease prevalence which is markedly higher in industrialized
countries. The rapid incidence increase of IBD over the last decades
is believed to be associated with the introduction of the “western diet”
across the world. Indeed, diet can influence intestinal inflammation
by different pathways essentially by altering gut microbiota, affecting
gut permeability or triggering immune responses 2 . Thus, it appears
that nutrients intake can modulate gut inflammatory status. Although
many approaches focus on the use of probiotics in intestinal inflammation,
only few studies target nutrients such as collagen peptides
in this context 3 .
Besides, an important number of studies
have been conducted to demonstrate
the anti-inflammatory activity of collagen
peptides in osteoarthritis but, until now, there
was no clear evidence on their impact on
intestinal inflammation.
Naticol ® Gut
Weishardt scientific team has worked on
transposing fish collagen peptides bioactivity
to gut inflammation and provide today solid
evidence that the new patented Naticol ®
Gut fish collagen peptides have a beneficial
effect in this axis. Indeed, Naticol ® Gut
reduces experimental colitis severity in an
immune system-dependent manner that
consequently leads to a healthier gut micro-
8 No. 1 April/May 2022