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Dominican Medicinal Plants: A Guide for Health Care Providers

by Jolene E. Yukes and Michael J. Balick, PhD

by Jolene E. Yukes and Michael J. Balick, PhD

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Laboratory and Preclinical Data: Coffea arabica<br />

Activity/Effect Preparation Design & Model Results Reference<br />

Antioxidant Green & roasted<br />

coffee (Coffea<br />

arabica & Coffea<br />

robusta)<br />

Daglia 2000<br />

Hypercholesterolemic<br />

REFERENCES<br />

Coffee lipids, nonsaponifiable<br />

matter, & diterpene<br />

alcohols; dissolved<br />

in olive oil or<br />

coconut oil<br />

In vitro (betacarotene-linoleic<br />

acid model) & ex<br />

vivo: rat liver cell<br />

microsome lipid<br />

peroxidation<br />

In vivo; adult male<br />

Syrian hamsters fed<br />

low & high<br />

saturated fat diets;<br />

250 µL<br />

administered daily<br />

by gavage<br />

Demonstrated very strong<br />

protective activity with<br />

acidified dark roasted coffee<br />

containing the most<br />

protective compounds<br />

whereas antioxidant activity<br />

was slightly higher in green<br />

coffee samples<br />

Demonstrated<br />

hypercholesterolemic<br />

activity; effect may be due to<br />

diterpenes in coffee lipids<br />

Ratnayake et al.<br />

1995<br />

Acevedo-Rodríguez, P. 1996. Flora of St. John, U.S. Virgin Islands. Memoirs of The New York Botanical Garden,<br />

Volume 78. Bronx, NY: NYBG Press.<br />

Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS, eds. 1998. The Complete<br />

German Commission E Monographs: Therapeutic <strong>Guide</strong> to Herbal Medicines. Austin: American Botanical<br />

Council and Boston: Integrative Medicine Communications, 685 pp.<br />

Brinker F. 1998. Herb Contraindications and Drug Interactions, 2 nd Ed. Sandy, OR: Eclectic Medica Publications.<br />

263 pp.<br />

Daglia M, Papetti A, Gregotti C, Berte F, Gazzani G. 2000. In vitro antioxidant and ex vivo protective activities of<br />

green and roasted coffee. Journal of Agricultural & Food Chemistry 48(5):1449-54.<br />

Rao SS, Welcher K, Zimmerman B, Stumbo P. 1998. Is coffee a colonic stimulant? Eur J Gastroenterol Hepatol<br />

10(2):113-8.<br />

Ratnayake WM, Pelletier G, Hollywood R, Malcolm S, Stavric B. 1995. Investigation of the effect of coffee lipids<br />

on serum cholesterol in hamsters. Food & Chemical Toxicology 33(3):195-201.<br />

Riedel W, Hogervorst E, Leboux R, Verhey, van Praag H, Jolles J. 1995. Caffeine attenuates scopolamine-induced<br />

memory impairment in humans. Psychopharmacology 122(2):158-68.<br />

Smith A, Thomas M, Perry K, Whitney H. 1997. Caffeine and the common cold. J Psychopharmacol 11(4):319-324.<br />

Gruenwald J, Brendler T, Jaenicke C, eds. 2004. Physicians’ Desk Reference <strong>for</strong> Herbal Medicines, Third Edition.<br />

Montvale, NJ: Thomson <strong>Health</strong>care, Inc. 988 pp.<br />

Yukes JE, Balick MJ, Kronenberg F, Reiff M, Johnson K. 2002-2003. Urban Ethnobotany Project, Phase III -<br />

<strong>Dominican</strong> herbal remedies <strong>for</strong> women's health. Unpublished field notes. Manuscript on file, The New<br />

York Botanical Garden, Bronx, NY.<br />

199

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