Dominican Medicinal Plants: A Guide for Health Care Providers

Activity/Effect Preparation Design & Model Results Reference
Antiulcer
Dried rhizome
hot water
extract; dose:
50.0 mg/kg;
administered
intragastrically
In vivo: male &
female rats with cold
stress-, aspirin- &
pylorus ligationinduced
ulcers
Active
Agrawal et al.
2000
Antiulcer
Antiulcer
Antiulcer
Antiviral
Antiviral
Antiviral
Carcinogenesis
inhibition
Central nervous
system stimulant
Chemokine
expression
Rhizome
acetone &
methanolic
extracts; dose:
1000 mg/kg of
each extract
Dried rhizome
ethanolic (95%)
extract; dose:
500.0 mg/kg
Fresh rhizome,
ethanolic (70%)
& acetone
extracts
Rhizome,
decoction
Dried rhizome
hexane extract
Lyophilized
extract of
rhizome
Dried rhizome
decoction; dose:
0.125%
administered in
drinking water
Dried rhizome,
ethanolic extract
(95%); 1.5 mL,
administered
intravenously
Fresh rhizome
aqueousethanolic
(1:1)
extract
In vivo: rats with
HCl-ethanol-induced
ulcers
In vivo: rats
In vivo: rats with
stress- (restraint) &
pylorus ligationinduced
ulcers
In vitro: cell culture;
virus-rotavirus
In vitro: cell culture,
plaque assay
In vitro: cell culture
In vivo: female mice
with spontaneous
mammary
tumorigenesis
Active
Active against aspirin-,
indomethacin- & cold
stress-induced ulcers
Active; ED 50 = 62.01
mg/kg
Active at a concentration
of 0.05 mg/mL
Active; showed antiviral
activity against rhinovirus
type 1-B
Active against influenza A
virus; effect mediated by
macrophage activation &
subsequent production of
TNF-alpha
Active; inhibited
carcinogenesis in mouse
mammary gland
Yamahara et al.
1988
Al Yahya et al.
1989
Sertie et al. 1992
Kim et al. 2000
Denyer et al.
1994
Imanishi et al.
2006
Nagasawa et al.
2002
In vivo: rabbits Active Emig 1931
In vitro: human
peripheral blood
mononuclear
leukocytes
Active; at a concentration
of 10.0 mg/mL showed
stimulation of interleukin-
6 formation & tumor
necrosis factor induction;
at 20.0 mg/mL, showed
stimulation of interleukin-
1 formation & GM-CSF
secretion
Chang et al.
1995
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