Dominican Medicinal Plants: A Guide for Health Care Providers

Laboratory and Preclinical Data: Zingiber officinale
Activity/Effect Preparation Design & Model Results Reference
Analgesic
Dried rhizome
juice; dose:
199.8
mg/animal,
administered
intragastrically
In vivo: mice; tail
flick response to
radiant heat model
Active; showed analgesic
effect equivalent to that of
10 mg/kg b.w. aspirin
Latifah 1987
Analgesic
Anesthetic
Anthelmintic
Antiatherosclerotic
& hypolipidemic
Antibacterial
Antibacterial
Dried rhizome
aqueousmethanolic
extract (1:1),
administered
subcutaneously
Rhizome, hot
water extract;
1.0%
concentration,
applied topically
Dried rhizome
saline extract
Dried rhizome,
aqueousethanolic
extract
(50%); dose:
500.0 mg/kg,
administered
intragastrically
Rhizome,
ethanolic extract
(80%)
Dried rhizome,
methanolic
extract
In vivo: mice;
inhibition of aceticacid
induced writhing
model
Active; at a dose of 10.0
g/kg showed analgesic
effects
Kasahara et al.
1983
Frog sciatic nerve Active Sugaya et al.
1979
Anisakis spp. larvae
(anisakiasis-causing
parasitic nematode)
In vivo: male
cholesterol-fed
rabbits
In vitro: agar plate
against Bacillus
subtilis, B. anthracis,
Staphylococcus
aureus, S.
epidermidis, S.
hemolyticus,
Salmonella typhi,
Escherichia coli,
Proteus mirabilis &
Pseudomonas
aeruginosa
In vitro: agar plate;
Helicobacter pylori
Active at a concentration
of 2.5%; showed 100%
larvicidal effect
Active; showed reduction
in atherogenic index from
4.7 to 1.2 & lowered LDL-
& total cholesterol levels
Active at a concentration
of 500.0 µg/disc
Active; MIC = 25.0 µg/mL
Kasuya et al.
1988
Sharma et al.
1996
Mascolo et al.
1989
Mahady et al.
2000
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