scientific program • symposia - American Society for Reproductive ...

SCIENTIFIC PROGRAM • INTERACTIVE SESSIONS
Wednesday, October 19, 2011 1:15 pm – 2:15 pm
Interactive Session
TREATMENT THROUGHOUT THE LIFE CYCLE OF KLINEFELTER
AND TURNER SYNDROME PATIENTS
Joint session presented by the Society for Male Reproduction and Urology
and the Pediatric and Adolescent Gynecology Special Interest Group
Rebecca Z. Sokol, M.D., M.P.H. (Chair)
University of Southern California Keck School of Medicine
Richard H. Reindollar, M.D.
Dartmouth Medical School
Jay I. Sandlow, M.D.
Medical College of Wisconsin
Needs Assessment and Description
The vast majority of Klinefelter syndrome (KS) and Turner
syndrome (TS) patients are considered sterile by the
onset of puberty. However, with newer sperm acquisition
techniques, KS patients now have the opportunity to
father biologic children; and pregnancies in TS patients
have been reported from spontaneous menstrual
cycles, assisted reproduction using their own oocytes,
and donor oocytes. In addition, several menstruating TS
patients have had superovulation, oocyte retrieval, and
oocyte cryopreservation in anticipation of future ovarian
insufficiency. Similarly, recent publications have suggested
the possibility of fertility preservation in prepubertal
and pubertal KS patients. However, these therapeutic
interventions are associated with potential risks, particularly
in the TS patient. Therefore, the need exists to educate
healthcare providers regarding the fertility options
available to these patients, as well as the success rates
and the potential risks, enabling healthcare providers to
appropriately provide screening and counseling to their
patients. Future registries are needed to best understand
these risks and help with accurate guidelines for the
reproductive care of these patients.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Discuss reproductive capabilities of patients with
Klinefelter syndrome and Turner syndrome.
2. Describe therapeutic options available for reproduction
by patients with these syndromes.
3. Consider future directions for reproductive treatments for
these patients.
ACGME COMPETENCY
Medical Knowledge
Patient Care
Room 224 A/B
93
TEST QUESTION:
1. A 30-year-old male with Klinefelter syndrome is referred
to you for discussion of fertility options. His female partner
is 29 years old with regular menstrual cycles. She has a
child from a previous relationship. His workup includes the
following levels: testosterone 215 ng/dL (normal 280-800);
estradiol 35 pg/mL (normal for males